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阿替卡因在内镜下鼻内泪囊鼻腔造口术中的应用:一项回顾性研究。

Application of articaine in endoscopic endonasal dacryocystorhinostomy: a retrospective study.

作者信息

Liu Shulin, Shui Li, Liu Zhaohui, Li Qi

机构信息

Chongqing Key Laboratory of Ophthalmology, Chongqing Eye Institute, Chongqing Branch (Municipality Division) of National Clinical Research Center for Ocular Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

出版信息

Front Med (Lausanne). 2024 Jul 31;11:1332793. doi: 10.3389/fmed.2024.1332793. eCollection 2024.

Abstract

BACKGROUND

To investigate the comparative effects of local anesthesia using lidocaine with adrenaline vs. articaine with adrenaline in endoscopic endonasal dacryocystorhinostomy (EN-DCR).

METHODS

This retrospective study included a total of 180 patients. These patients were categorized into two groups: the lidocaine group, which received 2% lidocaine (1:100,000 adrenaline), and the articaine group, which received 4% articaine (1:100,000 adrenaline) for local anesthesia. The study compared anesthesia efficacy, intraoperative pain levels, intraoperative bleeding, as well as differences in heart rate and blood pressure between the two groups.

RESULTS

The articaine group demonstrated a significantly lower visual analog scale (VAS) pain score when compared to the lidocaine group, measuring at 4.4 ± 0.6 cm vs. 5.0 ± 1.0 cm, respectively ( < 0.0001). Additionally, the articaine group exhibited a higher anesthesia efficacy compared to the lidocaine group (89.0% vs. 76.6%,  = 0.0487). Notably, the articaine group experienced less nasal mucosal bleeding during the surgery in contrast to the lidocaine group ( = 0.004). However, there were no statistically significant differences in changes in blood pressure and heart rate between the two groups ( > 0.05).

CONCLUSION

This study demonstrated that 4% articaine (1:100,000 adrenaline) has superior clinical effectiveness in comparison to 2% lidocaine (1:100,000 adrenaline) in EN-DCR.

摘要

背景

探讨利多卡因加肾上腺素与阿替卡因加肾上腺素局部麻醉在内镜下鼻内泪囊鼻腔造口术(EN-DCR)中的比较效果。

方法

这项回顾性研究共纳入180例患者。这些患者被分为两组:利多卡因组,接受2%利多卡因(1:100,000肾上腺素);阿替卡因组,接受4%阿替卡因(1:100,000肾上腺素)进行局部麻醉。该研究比较了两组的麻醉效果、术中疼痛程度、术中出血情况以及心率和血压的差异。

结果

与利多卡因组相比,阿替卡因组的视觉模拟评分(VAS)疼痛评分显著更低,分别为4.4±0.6厘米和5.0±1.0厘米(<0.0001)。此外,与利多卡因组相比,阿替卡因组的麻醉效果更高(89.0%对76.6%,P = 0.0487)。值得注意的是,与利多卡因组相比,阿替卡因组在手术过程中鼻黏膜出血更少(P = 0.004)。然而,两组之间的血压和心率变化没有统计学显著差异(P>0.05)。

结论

本研究表明,在EN-DCR中,4%阿替卡因(1:100,000肾上腺素)比2%利多卡因(1:100,000肾上腺素)具有更好的临床效果。

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