Islam Nazmul, Zamir Rausan, Faruque Md Omar
Department of Nutrition and Food Technology, Jashore University of Science and Technology, Jashore, Bangladesh.
Department of General Educational Development, Daffodil International University, Dhaka, Bangladesh.
Evid Based Complement Alternat Med. 2024 Jan 12;2024:6507185. doi: 10.1155/2024/6507185. eCollection 2024.
The present study evaluates the human health risk of metals in locally consumed herbal preparations used to treat diabetes. Atomic absorption spectroscopy (AAS) was used after microwave-assisted digestion to mineralize the samples. Toxic metal assessment was done by adopting mathematical modeling for carcinogenic and noncarcinogenic risks in the exposed population and comparing the raw results with maximum residue limits (MRLs) set by regulatory authorities. Hazard quotient (HQ) values for Fe, Hg, Cu, Pb, and Zn were recorded above 1. Noncarcinogenic health risks remain in 29% of samples for Fe, 67% of samples for Hg, 17% of samples for Cu, 33% of samples for Pb, and 4% of samples for Zn. Hazard index (HI) values in 33% of samples were above 1. Carcinogenic risks for Pb, Cr, Cd, and Ni were higher than the acceptable limit (1 × 10). Carcinogenic health risks exist in 54% of samples for Pb, 58% of samples for Cr, 46% of samples for Cd, and 58% of samples for Ni. MRLs for metals were crossed in samples in varying degrees. This is a harrowing account and may put public health safety at risk. Considering these facts, there should be more investigation into toxic metals in other frequently marketed herbal drugs in the antidiabetic and other therapeutic classes. Pre- and postmarket monitoring strategies for the preparations should also be in place to ensure safe consumption.
本研究评估了当地用于治疗糖尿病的草药制剂中金属对人体健康的风险。采用微波辅助消解后，使用原子吸收光谱法（AAS）对样品进行矿化处理。通过对暴露人群的致癌和非致癌风险采用数学模型，并将原始结果与监管机构设定的最大残留限量（MRLs）进行比较，来进行有毒金属评估。铁、汞、铜、铅和锌的危害商（HQ）值记录在1以上。铁的非致癌健康风险存在于29%的样品中，汞为67%，铜为17%，铅为33%，锌为4%。33%的样品危害指数（HI）值高于1。铅、铬、镉和镍的致癌风险高于可接受限值（1×10）。铅的致癌健康风险存在于54%的样品中，铬为58%，镉为46%，镍为58%。样品中金属的MRLs在不同程度上被超过。这是一个令人痛心的情况，可能会使公众健康安全面临风险。考虑到这些事实，应该对其他常见的抗糖尿病和其他治疗类别的市售草药中的有毒金属进行更多调查。还应制定制剂上市前和上市后的监测策略，以确保安全消费。
