Division of Vascular Neurology, Department of Neurology (J.F., Z.L.), Beijing Tiantan Hospital, Capital Medical University, China.
China National Clinical Research Center for Neurological Diseases (Z.L.), Beijing Tiantan Hospital, Capital Medical University, China.
Stroke. 2024 Oct;55(10):2547-2557. doi: 10.1161/STROKEAHA.124.046679. Epub 2024 Aug 15.
Low-intensity focused ultrasound represents groundbreaking medical advancements, characterized by its noninvasive feature, safety, precision, and broad neuromodulatory capabilities. This technology operates through mechanisms, for example, acoustic radiation force, cavitation, and thermal effects. Notably, with the evolution of medical technology, ultrasound neuromodulation has been gradually applied in treating central nervous system diseases, especially stroke. Furthermore, burgeoning research areas such as sonogenetics and nanotechnology show promising potential. Despite the benefit of low-intensity focused ultrasound the precise biophysical mechanism of ultrasound neuromodulation still need further exploration. This review discusses the recent and ongoing developments of low-intensity focused ultrasound for neurological regulation, covering the underlying rationale to current utility and the challenges that impede its further development and broader adoption of this promising alternative to noninvasive therapy.
低强度聚焦超声代表了具有突破性的医学进展，其具有非侵入性、安全性、精确性和广泛的神经调节能力等特点。该技术通过声辐射力、空化和热效应等机制来实现。值得注意的是，随着医学技术的发展，超声神经调节已逐渐应用于中枢神经系统疾病的治疗，特别是中风。此外，声遗传学和纳米技术等新兴研究领域也显示出了广阔的应用前景。尽管低强度聚焦超声具有许多优势，但超声神经调节的确切生物物理机制仍需进一步探索。本文综述了低强度聚焦超声在神经调节方面的最新研究进展，包括其潜在的作用机制、当前的应用情况以及限制其进一步发展和广泛应用的挑战。
