Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Republic of Korea.
PLoS One. 2024 Aug 15;19(8):e0306828. doi: 10.1371/journal.pone.0306828. eCollection 2024.
This study aims to compare outcomes following a negative surveillance MRI study by surgery-MRI interval and investigate factors associated with second breast cancers in women with a personal history of breast cancer (PHBC).
This retrospective study included 1552 consecutive women (mean age, 53 years) with a PHBC and a negative prevalence surveillance breast MRI result between August 2014 and December 2016. The incidence and characteristics of second breast cancers were reviewed and compared according to surgery-MRI interval (< 3 years vs ≥ 3 years). Logistic regression analysis was used to investigate associations with clinical-pathologic characteristics.
Twenty-five second breast cancers occurred after negative MRI. The incidence of second breast cancers or local-regional recurrence did not significantly differ by surgery-MRI interval. The median intervals between MRI to second breast cancer detection showed no significant difference between the two groups (surgery-MRI interval <3 years vs. ≥ 3 years). Two node-positive second breast cancers were detected in the group with <3 years interval. BRCA mutation status, receipt of breast-conserving surgery, and adjuvant chemotherapy (all p < .05) were significant factors associated with the development of second breast cancers.
Outcomes following a negative surveillance MRI did not differ by surgery-MRI interval. BRCA mutation status, receipt of breast-conserving surgery and adjuvant chemotherapy were independently associated with the risk of developing second breast cancers after negative surveillance MRI.
本研究旨在比较手术-磁共振成像（MRI）间隔时间对阴性监测 MRI 研究后结局的影响，并探讨与乳腺癌个人史（PHBC）女性中第二乳腺癌相关的因素。
本回顾性研究纳入了 1552 例连续 PHBC 女性（平均年龄 53 岁），她们在 2014 年 8 月至 2016 年 12 月期间进行了阴性预发性乳腺 MRI 监测。根据手术-MRI 间隔时间（<3 年与≥3 年），回顾并比较了第二乳腺癌的发生率和特征。采用逻辑回归分析探讨与临床病理特征的关联。
25 例女性在阴性 MRI 后发生了第二乳腺癌。手术-MRI 间隔时间对第二乳腺癌或局部区域复发的发生率无显著影响。两组之间 MRI 至第二乳腺癌检测的中位间隔时间无显著差异（手术-MRI 间隔时间<3 年与≥3 年）。在间隔时间<3 年的组中，检测到 2 例淋巴结阳性的第二乳腺癌。BRCA 基因突变状态、接受保乳手术和辅助化疗（均 p<0.05）是与第二乳腺癌发生相关的显著因素。
阴性监测 MRI 后的结局与手术-MRI 间隔时间无关。BRCA 基因突变状态、接受保乳手术和辅助化疗是阴性监测 MRI 后发生第二乳腺癌的独立相关因素。
