Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, People's Republic of China.
Department of Chemistry and Pharmacy, Julius-Maximilians-University Würzburg, Röntgenring 11, 97070 Würzburg, Germany.
Nanotechnology. 2024 Sep 10;35(48). doi: 10.1088/1361-6528/ad6fa1.
As a part of the immune system, leukocytes (LEs) have the features of circumvention of immunogenicity as well as recruitment to sites of inflammation during infection and tumorigenesis. Utilizing LEs as vehicles to carry theranostic agents is a promising strategy for highly efficient targeted delivery and treatment for inflammation and cancer. Specifically, the LEs, similar to 'Trojan horses', can bypass the immune system and thus enhance the therapeutic effects on inflammation and cancer. In this context, the latest progress of LEs-based delivery systems for improving theranostics of inflammations and cancers is summarized, includingincubation andinternalization strategy. Although the therapeutic efficacy of LEs-based delivery systems has been achieved, the system construction is complex and the effect is not fulfilling demand completely. Encouragingly, a most recent work reported that the supramolecular arrangement of proteins on the nanocarriers would drive them to be selectively uptaken by neutrophils, opening a new avenue for diagnosis and treatment of inflammation. Moreover, enucleated cells are considered as the biomimetic drug delivery vehicle to retain the organelles for a range of diseases in a safe, controllable and effective manner. These novel findings provide more opportunities for researchers to rethink and redesign the LEs-based delivery systems to overcome existing limitations and broaden their usage, especially in clinical medicine.
作为免疫系统的一部分，白细胞 (LE) 具有规避免疫原性的特性，并且在感染和肿瘤发生时能够募集到炎症部位。利用 LE 作为载体携带治疗药物是一种很有前途的策略，可以实现高效靶向递药和炎症及癌症的治疗。具体来说，LE 类似于“特洛伊木马”，可以绕过免疫系统，从而增强对炎症和癌症的治疗效果。在这方面，总结了基于 LE 的递药系统在改善炎症和癌症的治疗效果方面的最新进展，包括孵育和内化策略。尽管基于 LE 的递药系统已经取得了治疗效果，但系统构建复杂，效果并不完全满足需求。令人鼓舞的是，最近的一项工作报道，纳米载体上蛋白质的超分子排列会促使它们被中性粒细胞选择性摄取，为炎症的诊断和治疗开辟了新途径。此外，去核细胞被认为是仿生药物递送载体，能够以安全、可控和有效的方式保留用于一系列疾病的细胞器。这些新发现为研究人员提供了更多的机会来重新思考和重新设计基于 LE 的递药系统，以克服现有局限性并拓宽其用途，特别是在临床医学中。
