Chen Yaxin, Qin Duotian, Zou Jianhua, Li Xiaobin, Guo Xin Dong, Tang Yi, Liu Chuang, Chen Wei, Kong Na, Zhang Can Yang, Tao Wei
Institute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China.
Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Adv Mater. 2023 Apr;35(17):e2207787. doi: 10.1002/adma.202207787. Epub 2023 Mar 2.
Leukocytes play a vital role in immune responses, including defending against invasive pathogens, reconstructing impaired tissue, and maintaining immune homeostasis. When the immune system is activated in vivo, leukocytes accomplish a series of orderly and complex regulatory processes. While cancer and inflammation-related diseases like sepsis are critical medical difficulties plaguing humankind around the world, leukocytes have been shown to largely gather at the focal site, and significantly contribute to inflammation and cancer progression. Therefore, the living leukocyte-based drug delivery systems have attracted considerable attention in recent years due to the innate and specific targeting effect, low immunogenicity, improved therapeutic efficacy, and low reverse effect. In this review, the recent advances in the development of living leukocyte-based drug delivery systems including macrophages, neutrophils, and lymphocytes as promising treatment strategies for cancer and inflammation-related diseases are introduced. The advantages, current challenges, and limitations of these delivery systems are also discussed, as well as perspectives on the future development of precision and targeted therapy in the clinics are provided. Collectively, it is expected that such kind of living cell-based drug delivery system is promising to improve or even revolutionize the treatments of cancers and inflammation-related diseases in the clinics.
白细胞在免疫反应中发挥着至关重要的作用，包括抵御入侵病原体、修复受损组织以及维持免疫稳态。当免疫系统在体内被激活时，白细胞会完成一系列有序且复杂的调节过程。尽管癌症和诸如败血症等与炎症相关的疾病是困扰全球人类的重大医学难题，但已表明白细胞在很大程度上会聚集在病灶部位，并对炎症和癌症进展有显著影响。因此，基于活白细胞的药物递送系统近年来因其固有的特异性靶向作用、低免疫原性、提高的治疗效果和低副作用而备受关注。在本综述中，介绍了基于活白细胞的药物递送系统（包括巨噬细胞、中性粒细胞和淋巴细胞）作为癌症和炎症相关疾病有前景的治疗策略的最新进展。还讨论了这些递送系统的优点、当前面临的挑战和局限性，并提供了临床精准和靶向治疗未来发展的展望。总体而言，预计这种基于活细胞的药物递送系统有望改善甚至彻底改变临床中癌症和炎症相关疾病的治疗。
