T-Cell Responses to Treponema pallidum Proteins in Blood and Skin to Advance Syphilis Vaccine Design: Learning From Nature.
作者信息
Salazar Juan C, Radolf Justin D
机构信息
Departments of Pediatrics.
Immunology, University of Connecticut School of Medicine, Farmington.
出版信息
J Infect Dis. 2024 Aug 16;230(2):275-277. doi: 10.1093/infdis/jiae246.
Abstract
摘要
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本文引用的文献
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In-Depth Proteome Coverage of In Vitro-Cultured and Quantitative Comparison Analyses with In Vivo-Grown Treponemes.体外培养梅毒螺旋体的深度蛋白质组覆盖及与体内生长梅毒螺旋体的定量比较分析
J Proteome Res. 2024 May 3;23(5):1725-1743. doi: 10.1021/acs.jproteome.3c00891. Epub 2024 Apr 18.
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Use of Epivolve phage display to generate a monoclonal antibody with opsonic activity directed against a subdominant epitope on extracellular loop 4 of BamA (TP0326).利用 Epivolve 噬菌体展示技术生成针对 BamA（TP0326）细胞外环 4 上一个亚显性表位的调理活性单克隆抗体。
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Syphilis.梅毒。
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Extracellular Loops of the Treponema pallidum FadL Orthologs TP0856 and TP0858 Elicit IgG Antibodies and IgG-Specific B-Cells in the Rabbit Model of Experimental Syphilis.苍白密螺旋体 FadL 同源物 TP0856 和 TP0858 的细胞外环在实验性梅毒兔模型中引发 IgG 抗体和 IgG 特异性 B 细胞。
mBio. 2022 Aug 30;13(4):e0163922. doi: 10.1128/mbio.01639-22. Epub 2022 Jul 12.
5
Structural Modeling of the Treponema pallidum Outer Membrane Protein Repertoire: a Road Map for Deconvolution of Syphilis Pathogenesis and Development of a Syphilis Vaccine.梅毒密螺旋体外膜蛋白组的结构建模：梅毒发病机制解析与梅毒疫苗开发的路线图。
J Bacteriol. 2021 Jul 8;203(15):e0008221. doi: 10.1128/JB.00082-21.
6
IFNγ Enhances CD64-Potentiated Phagocytosis of Opsonized with Human Syphilitic Serum by Human Macrophages.干扰素γ增强人巨噬细胞对用人梅毒血清调理的物质的CD64增强吞噬作用。
Front Immunol. 2017 Oct 5;8:1227. doi: 10.3389/fimmu.2017.01227. eCollection 2017.
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The Treponema pallidum Outer Membrane.梅毒螺旋体外膜。
Curr Top Microbiol Immunol. 2018;415:1-38. doi: 10.1007/82_2017_44.
8
A Homology Model Reveals Novel Structural Features and an Immunodominant Surface Loop/Opsonic Target in the Treponema pallidum BamA Ortholog TP_0326.一种同源模型揭示了梅毒螺旋体BamA直系同源物TP_0326中的新型结构特征和一个免疫显性表面环/调理素靶点。
J Bacteriol. 2015 Jun;197(11):1906-20. doi: 10.1128/JB.00086-15. Epub 2015 Mar 30.
9
Global estimates of syphilis in pregnancy and associated adverse outcomes: analysis of multinational antenatal surveillance data.全球妊娠梅毒估计数及相关不良结局：多国产前监测数据分析。
PLoS Med. 2013;10(2):e1001396. doi: 10.1371/journal.pmed.1001396. Epub 2013 Feb 26.
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Immune evasion and recognition of the syphilis spirochete in blood and skin of secondary syphilis patients: two immunologically distinct compartments.二期梅毒患者血液和皮肤中梅毒螺旋体的免疫逃逸与识别：两个免疫上截然不同的隔室。
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