Aramberri Jaime, Lauzirika Gorka, Illarramendi Igor, Mendicute Javier
Miranza Begitek, Donostia-San Sebastián, Spain.
Miranza Ókular, Vitoria-Gasteiz, Spain.
Eur J Ophthalmol. 2025 Mar;35(2):474-481. doi: 10.1177/11206721241267360. Epub 2024 Aug 15.
To describe and compare corneal densitometry, subjective refraction, visual acuity, and corneal higher order aberrations (HOA) after corneal refractive surgery using either alcohol-assisted photorefractive keratectomy (aaPRK) or single-step transepithelial PRK (tPRK).
We conducted a retrospective and observational study. We analyzed 120 right eyes from 120 healthy consecutive myopic patients who underwent aaPRK or tPRK to correct myopia of up to 6 diopters and astigmatism of up to 2 diopters. The WaveLight EX500 excimer laser (Alcon Laboratories, Inc.) was used in all cases. Visual acuity, subjective refraction, and Pentacam AXL® measurements were performed at the preoperative visit and at 6-months follow-up visit. Pentacam AXL® software was used to assess corneal optical density in various annuli for different corneal depths and anterior corneal HOA (6 mm area of analysis).
Preoperative spherical equivalent values were similar between groups preoperatively (-3.07 ± 1.52 and -3.38 ± 1.46 in the aaPRK and tPRK groups, respectively). There were no statistically significant differences in visual acuity and postoperative refraction between groups. Postoperative corneal densitometry did not show statistically significant differences in any of the areas studied and both surgical procedures obtained similar results. However, analysis of HOA showed statistically significant differences between the techniques (1.42 ± 0.39 and 1.80 ± 0.62 for the aaPRK and tPRK groups, respectively; = 0.000).
Both aaPRK and single-step tPRK gave comparable visual, refractive, and corneal density outcomes. Some differences were observed in HOA but were not clinically relevant.
描述并比较使用酒精辅助准分子原位角膜磨镶术（aaPRK）或单步经上皮准分子原位角膜磨镶术（tPRK）进行角膜屈光手术后的角膜密度测量、主观验光、视力及角膜高阶像差（HOA）。
我们进行了一项回顾性观察研究。分析了120例连续的健康近视患者的120只右眼，这些患者接受了aaPRK或tPRK手术以矫正最高6屈光度的近视和最高2屈光度的散光。所有病例均使用威视EX500准分子激光（爱尔康实验室公司）。在术前及术后6个月随访时进行视力、主观验光及Pentacam AXL®测量。使用Pentacam AXL®软件评估不同角膜深度各环带的角膜光学密度及角膜前表面HOA（分析区域为6 mm）。
术前两组的等效球镜值相似（aaPRK组和tPRK组分别为-3.07±1.52和-3.38±1.46）。两组间视力及术后验光无统计学显著差异。术后角膜密度测量在任何研究区域均未显示出统计学显著差异，两种手术方法获得了相似的结果。然而，HOA分析显示两种技术之间存在统计学显著差异（aaPRK组和tPRK组分别为1.42±0.39和1.80±0.62；P = 0.000）。
aaPRK和单步tPRK在视力、屈光及角膜密度结果方面相当。在HOA方面观察到了一些差异，但不具有临床相关性。
