Li Bing, Li Wei, Wang Jie, Zhang Xianfeng, Zheng Wei, Liu Chaomeng, Yan Baoping, Chen Xueyan
Hebei Provincial Mental Health Center, Baoding, China.
Hebei Key Laboratory of Major Mental and Behavioral Disorders, Baoding, China.
Alpha Psychiatry. 2024 Jun 1;25(3):421-428. doi: 10.5152/alphapsychiatry.2024.241613. eCollection 2024 Jun.
This study aimed to elucidate the risk factors associated with alcohol use disorders (AUDs) among inpatients with schizophrenia at a specialized mental hospital in Baoding city, China.
This cross-sectional survey comprised 301 comorbid patients. Three binary logistic regression models were used to investigate the factors linked to AUDs in patients with schizophrenia. Propensity score matching analysis was conducted to validate inconsistent variables identified by the regression models.
Significant differences were observed between the comorbid and non-comorbid groups concerning sex ( < .001), disposition ( = .049), smoking habits ( < .001), place of residence ( = .010), family relationships ( = .002), family history of mental disorders (.008), history of alcoholism ( = .003), onset latency ( = .005), impulsivity ( < .001), suicide or self-injury history ( < .001), and obvious aggressive behavior ( < .001) in univariate analyses. The area under the curve values for the three regression models were 0.83 ( < .001), 0.80 ( < .001), and 0.81 ( < .001), respectively. Binary logistic regression and propensity score matching analyses indicated that introverted disposition, smoking, acute onset, impulsivity, and suicide or self-injury history were independent risk factors associated with AUDs in inpatients with schizophrenia with an odds ratio of > 1.
Introverted disposition, smoking, acute onset, impulsivity, and suicide or self-injury history were independently associated with the AUDs in inpatients with schizophrenia. Future studies should prioritize longitudinal studies to discern the evolving dynamics of potential confounding risk factors.
本研究旨在阐明中国保定市一家专科医院中精神分裂症住院患者酒精使用障碍（AUDs）的相关危险因素。
这项横断面调查纳入了301例合并症患者。使用三个二元逻辑回归模型来研究精神分裂症患者中与AUDs相关的因素。进行倾向得分匹配分析以验证回归模型识别出的不一致变量。
在单因素分析中，合并症组和非合并症组在性别（<.001）、性格（=.049）、吸烟习惯（<.001）、居住地点（=.010）、家庭关系（=.002）、精神障碍家族史（.008）、酗酒史（=.003）、发病潜伏期（=.005）、冲动性（<.001）、自杀或自伤史（<.001）以及明显攻击行为（<.001）方面存在显著差异。三个回归模型的曲线下面积值分别为0.83（<.001）、0.80（<.001）和0.81（<.001）。二元逻辑回归和倾向得分匹配分析表明，内向性格、吸烟、急性起病、冲动性以及自杀或自伤史是精神分裂症住院患者中与AUDs相关的独立危险因素，比值比>1。
内向性格、吸烟、急性起病、冲动性以及自杀或自伤史与精神分裂症住院患者的AUDs独立相关。未来研究应优先进行纵向研究，以识别潜在混杂危险因素的演变动态。
