Wenzhou Medical University, Wenzhou, China.
Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China.
Technol Cancer Res Treat. 2024 Jan-Dec;23:15330338241274289. doi: 10.1177/15330338241274289.
In recent years, the development of drug-eluting embolization beads that can be imaged has become a hot research topic in regard to meeting clinical needs. In our previous study, we successfully developed nano-assembled microspheres (NAMs) for multimodal imaging purposes. NAMs can not only be visualized under CT/MR/Raman imaging but can also load clinically required doses of doxorubicin. It is important to systematically compare the pharmacokinetics of NAMs with those of commercially available DC Beads and CalliSpheres to evaluate the clinical application potential of NAMs. In our study, we compared NAMs with two types of drug-eluting beads (DEBs) in terms of irinotecan, drug-loading capacity, release profiles, microsphere diameter variation, and morphological characteristics. Our results indicate that NAMs had an irinotecan loading capacity similar to those of DC Beads and CalliSpheres but exhibited better sustained release in vitro. NAMs have great potential for application in transcatheter arterial chemoembolization for the treatment of colorectal cancer liver metastases.
近年来，能够成像的载药栓塞微球的发展成为满足临床需求的热门研究课题。在我们之前的研究中，我们成功地开发了用于多模态成像的纳米组装微球（NAMs）。NAMs 不仅可以在 CT/MR/Raman 成像下可视化，还可以负载临床所需剂量的阿霉素。系统地比较 NAMs 与市售的 DC Beads 和 CalliSpheres 的药代动力学，评估 NAMs 的临床应用潜力非常重要。在我们的研究中，我们比较了 NAMs 与两种载药微球（DEBs）在伊立替康、载药量、释放曲线、微球直径变化和形态特征方面的差异。结果表明，NAMs 的伊立替康载药量与 DC Beads 和 CalliSpheres 相似，但在体外表现出更好的持续释放。NAMs 在经导管动脉化疗栓塞治疗结直肠癌肝转移方面具有很大的应用潜力。
