School of Cardiovascular and Metabolic Health, BHF Glasgow Cardiovascular, Research Centre, College of Medical, Veterinary and Life Sciences.
School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland.
Curr Opin Clin Nutr Metab Care. 2024 Nov 1;27(6):486-491. doi: 10.1097/MCO.0000000000001065. Epub 2024 Aug 5.
This review aims to explore the latest research investigating the effects of marine-derived long-chain n -3 polyunsaturated fatty acid (LC n -3 PUFA) supplementation on neuromuscular function in older adults.
Ageing results in a decline in skeletal muscle strength and mass. There is growing evidence that LC n -3 PUFA supplementation increases muscle strength and mass in healthy older adults, yet the mechanisms underlying these effects remain elusive. Recent studies investigating LC n -3 PUFA supplementation have demonstrated effects on neuromuscular function such as increases in the compound muscle action potential (M-wave) amplitude and surface electromyography alongside increases in muscular strength. Therefore, evidence suggests that LC n -3 PUFA may elicit a beneficial effect at the neuromuscular junction and possess neuroprotective properties in older adults.
LC n -3 PUFA supplementation may increase or maintain neuromuscular function throughout the ageing process. Further research is warranted to investigate the long-term effects LC n -3 PUFA supplementation on neuromuscular outcomes such as single motor unit properties and cortical/supraspinal networks, utilizing state-of-the-art techniques in neuromuscular physiology.
本综述旨在探讨最新研究，以探究海洋来源的长链 n-3 多不饱和脂肪酸（LC n-3PUFA）补充对老年人神经肌肉功能的影响。
衰老会导致骨骼肌力量和质量下降。越来越多的证据表明，LC n-3PUFA 补充剂可增加健康老年人的肌肉力量和质量，但这些影响的机制仍不清楚。最近研究 LC n-3PUFA 补充剂对神经肌肉功能的影响，如复合肌肉动作电位（M 波）幅度和表面肌电图的增加，以及肌肉力量的增加。因此，有证据表明，LC n-3PUFA 可能在神经肌肉接头处产生有益的影响，并具有老年人的神经保护特性。
LC n-3PUFA 补充剂可能会增加或维持整个衰老过程中的神经肌肉功能。需要进一步研究，以利用神经肌肉生理学的最新技术，调查 LC n-3PUFA 补充对神经肌肉结果（如单个运动单位特性和皮质/皮质下网络）的长期影响。
