Institute of Nutrition & Health, Qingdao University, Qingdao, China; School of Public Health, Qingdao University, Qingdao, China.
Songshan Hospital of Qingdao University, Qingdao, China.
Prostaglandins Leukot Essent Fatty Acids. 2021 Feb;165:102249. doi: 10.1016/j.plefa.2021.102249. Epub 2021 Jan 12.
The results of randomized controlled trials (RCTs) investigating supplemental n-3 polyunsaturated fatty acids (PUFA) on muscle mass and function have been inconsistent. The present study aimed to quantitatively evaluate the effect of n-3 PUFA supplementation on indicators of muscle mass and function in healthy subjects. A systematic literature search was conducted up to July 2020 with databases of PubMed and Web of science. The random-effects model was implemented to calculate the weighted mean difference of net change of indicators regarding muscle mass and function. A total of nine studies (thirteen treatment groups) with 2067 participants were included for data analysis. The summary estimate showed that n-3 PUFA supplementation significantly increased the grip strength (1.17 kg; 95% CI: 0.27, 2.08 kg). Non-significant effect was observed with respect to muscle mass parameters, including fat mass (-0.67 kg; 95% CI: -2.20, 0.87 kg) and lean mass (0.33 kg; 95% CI: -0.35, 1.00 kg). Regarding muscle function indicators, there were non-significant effects on walking speed (-0.01 m•s; 95% CI: -0.03, 0.01 m•s), time up and go test (-0.25 s; 95% CI: -0.55, 0.04 s), respectively. The findings of this study indicated that supplementation with n-3 PUFA might have beneficial effects to improve muscle mass and function in healthy participants. However, there was no significant improvement in the subjects' muscle mass. Whether n-3 PUFA supplementation has favorable effects in participants with sarcopenia are warranted to be further investigated.
随机对照试验（RCTs）的结果表明，补充 n-3 多不饱和脂肪酸（PUFA）对肌肉质量和功能的影响不一致。本研究旨在定量评估 n-3 PUFA 补充剂对健康受试者肌肉质量和功能指标的影响。系统检索了 PubMed 和 Web of science 数据库，检索时间截至 2020 年 7 月。采用随机效应模型计算肌肉质量和功能指标净变化的加权均数差。共有 9 项研究（13 个治疗组）的 2067 名参与者纳入数据分析。汇总估计显示，n-3 PUFA 补充剂可显著增加握力（1.17kg；95%CI：0.27，2.08kg）。肌肉质量参数，包括脂肪量（-0.67kg；95%CI：-2.20，0.87kg）和瘦体量（0.33kg；95%CI：-0.35，1.00kg），未见显著效果。对于肌肉功能指标，步行速度（-0.01m•s；95%CI：-0.03，0.01m•s）和起立-行走测试（-0.25s；95%CI：-0.55，0.04s）的变化也无显著影响。本研究结果表明，n-3 PUFA 补充剂可能对改善健康参与者的肌肉质量和功能有益。然而，对受试者肌肉质量的改善没有明显作用。n-3 PUFA 补充剂是否对肌少症患者有有利影响，尚需进一步研究。
