Lee Ji Hye, Kim Joo-Young, Hwang Bo-Een, Kim Ju-Young, Kim Rae-Young, Kim Mirinae, Park Young-Gun, Park Young-Hoon
Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Retina. 2024 Dec 1;44(12):2076-2085. doi: 10.1097/IAE.0000000000004249.
To assess the longitudinal surgical outcomes of macular telangiectasia Type 2 macular hole (MacTel-MH) and compare them with those of idiopathic MH.
This retrospective, single-tertiary center study included patients who underwent MH surgery between January 2015 and September 2023. Patients with characteristic optical coherence tomography findings of MacTel in both eyes or those who underwent fluorescence angiography were classified as having MacTel MH. Baseline and postoperative best-corrected visual acuity and optical coherence tomography parameters were reviewed.
Totally, 27 and 243 eyes with MacTel and idiopathic MH, respectively, were included. Macular hole closure rate was better achieved in idiopathic than in MacTel MH group at two years postoperatively. Temporal recovery of ellipsoid zone and external limiting membrane was more prominent in MacTel than in idiopathic MH group. Statistically significant visual acuity improvement was seen between three months and two years postoperatively in MacTel MH group.
To the best of our knowledge, this is the first study to analyze the surgical outcomes of MacTel MH in both anatomical and functional aspects and compare them with patients with idiopathic MH. Postoperative microglia change would have affected the restoration of outer retinal layer of patients; however, further studies are needed for clarification.
评估2型黄斑毛细血管扩张症性黄斑裂孔（MacTel-MH）的纵向手术效果，并将其与特发性黄斑裂孔的手术效果进行比较。
这项回顾性单三级中心研究纳入了2015年1月至2023年9月期间接受黄斑裂孔手术的患者。双眼具有MacTel特征性光学相干断层扫描结果的患者或接受荧光血管造影的患者被归类为患有MacTel-MH。回顾了基线和术后最佳矫正视力以及光学相干断层扫描参数。
总共纳入了分别患有MacTel和特发性黄斑裂孔的27只眼和243只眼。术后两年时，特发性黄斑裂孔组的黄斑裂孔闭合率优于MacTel-MH组。MacTel组椭圆体带和外界膜的颞侧恢复比特发性黄斑裂孔组更明显。MacTel-MH组术后3个月至2年之间视力有统计学意义的改善。
据我们所知，这是第一项从解剖学和功能方面分析MacTel-MH手术效果并将其与特发性黄斑裂孔患者进行比较的研究。术后小胶质细胞变化可能影响了患者外层视网膜的恢复；然而，需要进一步研究以阐明这一点。
