Bertolani Yann, Arnaiz-Camacho Albert, Fernández-Engroba Jorge, García-Arumí Jose, Zapata Miguel-Ángel
Ophthalmology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Eur J Ophthalmol. 2025 Mar;35(2):NP33-NP38. doi: 10.1177/11206721241301933. Epub 2024 Nov 26.
To describe the successful use of plasma rich in growth factors (PRGF-Endoret®) and internal limiting membrane peeling for full thickness macular hole in Macular Telangiectasia type 2.
A case report of a full thickness macular hole (FTMH) associated with Macular Telangiectasia (MacTel) type 2 is described. 25-G vitrectomy with internal limiting membrane (ILM) peeling and use of (PRGF-Endoret®) was performed. Several ophthalmological visits were conducted and multiple diagnostic tests were carried out including optical coherence tomography (OCT) and fluorescein angiography. A 72-year-old man under follow-up for MacTel type 2 presented with worsening vision in his left eye, with a best visual corrected acuity (BVCA) of 20/80. OCT demonstrated a FTMH in the left eye measuring 264 µm. A 25-gauge pars plana vitrectomy surgery was performed with ILM peeling, use of PRGF-Endoret® and tamponade with 20% sulfur hexafluoride (SF6). Three weeks after surgery, complete anatomical closure was observed with a BVCA of 20/40, which improved to 20/25 one year after the surgery.
The use of PRGF associated with ILM peeling may be a useful tool in the treatment of macular holes associated with MacTel Type 2 with excellent anatomical and functional outcomes.
描述富含生长因子血浆（PRGF-Endoret®）联合内界膜剥除术在2型黄斑毛细血管扩张症全层黄斑裂孔治疗中的成功应用。
描述了1例与2型黄斑毛细血管扩张症（MacTel）相关的全层黄斑裂孔（FTMH）病例。实施了25G玻璃体切除术联合内界膜（ILM）剥除及PRGF-Endoret®的应用。进行了多次眼科检查并开展了多项诊断测试，包括光学相干断层扫描（OCT）和荧光素血管造影。1例接受2型MacTel随访的72岁男性，左眼视力恶化，最佳矫正视力（BVCA）为20/80。OCT显示左眼有一个直径264 µm的FTMH。实施了25G经平坦部玻璃体切除术，联合ILM剥除、PRGF-Endoret®的应用及20%六氟化硫（SF6）填塞。术后3周，观察到解剖结构完全闭合，BVCA为20/40，术后1年提高到20/25。
PRGF联合ILM剥除术可能是治疗与2型MacTel相关黄斑裂孔的有效方法，可取得优异的解剖和功能预后。
