Qilu University of Technology (Shandong Academy of Science), Shandong Analysis and Test Centre, Jinan, Shandong, 250014, China; Institute of Food Safety, Chinese Academy of Inspection and Quarantine, Beijing 100176, China.
Institute of Food Safety, Chinese Academy of Inspection and Quarantine, Beijing 100176, China.
Food Chem. 2024 Dec 15;461:140857. doi: 10.1016/j.foodchem.2024.140857. Epub 2024 Aug 12.
The thermal-responsive magnetic molecularly imprinted polymer (TrMMIP) sorbent was synthesized by surface imprinting method, and then used for magnetic solid-phase extraction (MSPE) and subsequent integrated into the ion source for elution and ionization. The shrinking-strength states change of the thermal-responsive polymer chain on TrMMIP alters the wettability of the sorbent when the working temperature crosses the lower critical solution temperature (LCST) of the polymer, and thus affects its behavior of in the extraction and clean-up process. The targeted analytes could be effectively extracted due to the high selectivity of MIPs and well dispersibility of polymer chain under the open state. Additionally, a hydrophilic polymer chain wrapped on the sorbent surface further protected target substances from co-elution during cleanup. Analytical methods for sulfonamide antibiotics (SAs) detection in complex food samples (milk, honey, fish) were developed, demonstrating potential for rapid and sensitive SAs analysis in diverse food and biological samples.
热响应磁性分子印迹聚合物（TrMMIP）通过表面印迹法合成，然后用于磁固相萃取（MSPE），并随后集成到离子源中进行洗脱和离子化。当工作温度超过聚合物的下临界溶液温度（LCST）时，热响应聚合物链的收缩强度状态改变改变了吸附剂的润湿性，从而影响其在萃取和净化过程中的行为。由于 MIPs 的高选择性和聚合物链在开放状态下的良好分散性，目标分析物可以被有效提取。此外，在吸附剂表面包裹的亲水性聚合物链进一步保护目标物质在净化过程中不被共洗脱。在复杂食品样品（牛奶、蜂蜜、鱼）中检测磺胺类抗生素（SAs）的分析方法被开发出来，表明其在各种食品和生物样品中进行快速、灵敏的 SAs 分析的潜力。
