Monga Suneeta, Andrei Sorina, Quinn Rebecka C, Khudiakova Valeria, Desai Riddhi, Srirangan Abiramy, Patel Sneha, Szatmari Peter, Butcher Nancy J, Krause Karolin R, Courtney Darren B, Offringa Martin, Elsman Ellen B M
Hospital for Sick Children, Toronto, Ontario, Canada; Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Hospital for Sick Children, Toronto, Ontario, Canada.
J Am Acad Child Adolesc Psychiatry. 2025 Feb;64(2):198-225. doi: 10.1016/j.jaac.2024.06.011. Epub 2024 Aug 14.
To systematically evaluate the measurement properties of 12 patient-reported outcome measures (PROMs) used to measure depression symptom severity in adolescents with depression. Depression symptom severity was chosen as the outcome of focus given its importance as an outcome to measure in adolescents with depression across clinical trials and/or care.
MEDLINE, PsycInfo, Embase, Scopus, CINAHL, and Cochrane were searched from year of inception up to December 7, 2023. Study appraisal (ie, risk of bias), evaluation of measurement properties, and evidence synthesis followed the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) guidelines. Included studies evaluated at least 1 of 9 measurement properties as detailed in the COSMIN taxonomy within a reported sample or subgroup of youth ages 12 to 24 years, with at least 40% meeting criteria for any depressive disorder.
Of the 15,560 records identified, 31 studies for 7 PROMs were included in the COSMIN appraisal. Although several PROMs have the potential to accurately measure depression symptom severity in adolescents with depression, at this time none of the PROMs can be recommended for use without further evaluative work. High-quality evidence was generally lacking, largely due to few or inconsistent findings, small sample sizes, and other methodological concerns.
This systematic review of the measurement properties of 12 PROMs used to measure depression symptom severity in adolescents with depression found that none of the PROMs can be recommended for use until further evaluative work is conducted. Clinicians and researchers should proceed with caution when using these PROMs.
This systematic review evaluated 12 patient report outcome measures (PROMs) commonly used to measure depression symptom severity in adolescents with depression. Only 7 of these PROMs had studies to evaluate; none of them had the necessary measurement properties to indicate that they could be recommended for use or that results could be trusted. The authors suggest that more evaluative work is required to ensure the validity of the measurement properties of the tools utilized to measure depression symptom severity in adolescents with depression. This work should include engagement of youth and caregivers in evaluation of the content validity (eg, the relevance, comprehensibility, and comprehensiveness) of these PROMs.
One or more of the authors of this paper self-identifies as a member of one or more historically underrepresented racial and/or ethnic groups in science. One or more of the authors of this paper self-identifies as a member of one or more historically underrepresented sexual and/or gender groups in science. We actively worked to promote sex and gender balance in our author group. We actively worked to promote inclusion of historically underrepresented racial and/or ethnic groups in science in our author group. The author list of this paper includes contributors from the location and/or community where the research was conducted who participated in the data collection, design, analysis, and/or interpretation of the work.
系统评价用于测量青少年抑郁症患者抑郁症状严重程度的12种患者报告结局指标（PROMs）的测量属性。鉴于抑郁症状严重程度作为跨临床试验和/或护理中测量青少年抑郁症患者结局的重要性，故将其选为重点结局指标。
检索MEDLINE、PsycInfo、Embase、Scopus、CINAHL和Cochrane数据库，检索时间从各数据库建库至2023年12月7日。研究评估（即偏倚风险）、测量属性评估和证据综合遵循基于共识的健康测量工具选择标准（COSMIN）指南。纳入的研究在12至24岁青少年的报告样本或亚组中评估了COSMIN分类法中详细列出的9种测量属性中的至少1种，且至少40%符合任何抑郁症诊断标准。
在识别出的15560条记录中，有31项针对7种PROMs的研究被纳入COSMIN评估。虽然几种PROMs有可能准确测量青少年抑郁症患者的抑郁症状严重程度，但目前在没有进一步评估工作的情况下，不能推荐使用任何一种PROMs。普遍缺乏高质量证据，主要原因是研究结果较少或不一致、样本量小以及其他方法学问题。
这项对用于测量青少年抑郁症患者抑郁症状严重程度的12种PROMs测量属性的系统评价发现，在进行进一步评估工作之前，不能推荐使用任何一种PROMs。临床医生和研究人员在使用这些PROMs时应谨慎行事。
本系统评价评估了常用于测量青少年抑郁症患者抑郁症状严重程度的12种患者报告结局指标（PROMs）。这些PROMs中只有7种有研究进行评估；它们都没有必要的测量属性来表明可以推荐使用或结果可信。作者建议需要进行更多评估工作，以确保用于测量青少年抑郁症患者抑郁症状严重程度的工具测量属性的有效性。这项工作应包括让青少年和照顾者参与评估这些PROMs的内容效度（如相关性、可理解性和全面性）。
本文的一位或多位作者自我认定为科学领域中一个或多个历史上代表性不足的种族和/或族裔群体的成员。本文的一位或多位作者自我认定为科学领域中一个或多个历史上代表性不足的性取向和/或性别群体的成员。我们积极努力促进作者群体中的性别平衡。我们积极努力促进作者群体中纳入科学领域历史上代表性不足的种族和/或族裔群体。本文的作者名单包括研究开展地点和/或社区的贡献者，他们参与了数据收集、设计、分析和/或对工作的解释。
