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全基因组变异研究和组织间通讯分析揭示了鸡产蛋性能的调控机制。

Genome-wide variation study and inter-tissue communication analysis unveil regulatory mechanisms of egg-laying performance in chickens.

机构信息

College of Animal Science and Technology, Henan Agricultural University, Zhengzhou, China.

College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, China.

出版信息

Nat Commun. 2024 Aug 16;15(1):7069. doi: 10.1038/s41467-024-50809-9.

DOI:10.1038/s41467-024-50809-9
PMID:39152103
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11329784/
Abstract

Egg-laying performance is of great economic importance in poultry, but the underlying genetic mechanisms are still elusive. In this work, we conduct a multi-omics and multi-tissue integrative study in hens with distinct egg production, to detect the hub candidate genes and construct hub molecular networks contributing to egg-laying phenotypic differences. We identifiy three hub candidate genes as egg-laying facilitators: TFPI2, which promotes the GnRH secretion in hypothalamic neuron cells; CAMK2D, which promotes the FSHβ and LHβ secretion in pituitary cells; and OSTN, which promotes granulosa cell proliferation and the synthesis of sex steroid hormones. We reveal key endocrine factors involving egg production by inter-tissue crosstalk analysis, and demonstrate that both a hepatokine, APOA4, and an adipokine, ANGPTL2, could increase egg production by inter-tissue communication with hypothalamic-pituitary-ovarian axis. Together, These results reveal the molecular mechanisms of multi-tissue coordinative regulation of chicken egg-laying performance and provide key insights to avian reproductive regulation.

摘要

产蛋性能在禽类中具有重要的经济意义，但潜在的遗传机制仍难以捉摸。在这项工作中，我们对产蛋性能不同的母鸡进行了多组学和多组织综合研究，以检测与产蛋表型差异相关的枢纽候选基因，并构建枢纽分子网络。我们鉴定出三个作为产蛋促进剂的枢纽候选基因：TFPI2，促进下丘脑神经元细胞中 GnRH 的分泌；CAMK2D，促进垂体细胞中 FSHβ和 LHβ的分泌；OSTN，促进颗粒细胞增殖和性激素的合成。通过组织间串扰分析，我们揭示了涉及产蛋的关键内分泌因子，并证实了载脂蛋白 A4 (APOA4) 和血管生成素样蛋白 2 (ANGPTL2) 这两种肝源因子和脂肪源因子都可以通过与下丘脑-垂体-卵巢轴的组织间通讯来增加产蛋量。总之，这些结果揭示了鸡产蛋性能的多组织协调调控的分子机制，为禽类生殖调控提供了关键见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6378/11329784/80d23d5f5942/41467_2024_50809_Fig7_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6378/11329784/80d23d5f5942/41467_2024_50809_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6378/11329784/19da47fcc922/41467_2024_50809_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6378/11329784/0b488a0aaa06/41467_2024_50809_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6378/11329784/49ccacf07fc2/41467_2024_50809_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6378/11329784/22e9c51a14f8/41467_2024_50809_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6378/11329784/0863d2449386/41467_2024_50809_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6378/11329784/8216e44cc73f/41467_2024_50809_Fig6_HTML.jpg
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