Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
Clin Gastroenterol Hepatol. 2019 Dec;17(13):2696-2703. doi: 10.1016/j.cgh.2019.03.046. Epub 2019 Apr 4.
Depression is a major health issue in the United States and is highly comorbid with gastrointestinal conditions. We collected data from the National Health and Nutrition Examination Survey (NHANES), a representative sample of the US population, to study the relationship between depression and bowel habits.
Using data from the NHANES (2009-2010), we identified 495 depressed and 4709 non-depressed adults who filled out the Bowel Health Questionnaire. Depression was defined according to a validated questionnaire. We used multivariable analysis, controlling for clinical and demographic variables, to evaluate the relationship between mood and bowel habits.
In our weighed sample, 24.6% of depressed individuals and 12.6% of non-depressed individuals reported disordered bowel habits. Chronic diarrhea was significantly more prevalent in depressed individuals (15.53%; 95% CI, 11.34%-20.90%) than non-depressed individuals (6.05%; 95% CI, 5.24%-6.98%; P = .0001). Chronic constipation was also more common in depressed individuals (9.10%; 95% CI, 7.02%-11.69%) than non-depressed individuals (6.55%; 95% CI, 5.55%-7.70% CI; P = .003). Mean depression scores in patients with chronic diarrhea (4.9 ± 5.8) and with chronic constipation (4.4 ± 4.93) were significantly higher than mean depression scores for individuals with normal bowel habits (3.2 ± 4.6) (P < .001). Moderate and severe depression were significantly associated with chronic diarrhea but not chronic constipation. Only mild depression was significantly associated with chronic constipation.
In an analysis of the NHANES database, we found a higher proportion of depressed individuals to have chronic diarrhea and constipation than non-depressed individuals; chronic diarrhea was more strongly associated with depression. Our findings provide support for the relationship between mood and specific bowel habits, accounting for multiple co-variables in a large sample of the general US population.
在美国，抑郁是一个主要的健康问题，且与胃肠道疾病高度共病。我们从国家健康和营养检查调查（NHANES）中收集了数据，这是美国人口的代表性样本，以研究抑郁与肠道习惯之间的关系。
我们使用 NHANES（2009-2010 年）的数据，确定了 495 名抑郁患者和 4709 名非抑郁患者，他们填写了肠道健康问卷。抑郁根据经过验证的问卷进行定义。我们使用多变量分析，控制临床和人口统计学变量，评估情绪与肠道习惯之间的关系。
在我们加权的样本中，24.6%的抑郁患者和 12.6%的非抑郁患者报告有肠道习惯紊乱。慢性腹泻在抑郁患者中明显更为常见（15.53%；95%置信区间，11.34%-20.90%）而非抑郁患者中更为常见（6.05%；95%置信区间，5.24%-6.98%；P=.0001）。慢性便秘在抑郁患者中也更为常见（9.10%；95%置信区间，7.02%-11.69%）而非抑郁患者中更为常见（6.55%；95%置信区间，5.55%-7.70%；P=.003）。慢性腹泻患者（4.9±5.8）和慢性便秘患者（4.4±4.93）的平均抑郁评分明显高于肠道习惯正常患者（3.2±4.6）（P<.001）。中度和重度抑郁与慢性腹泻显著相关，但与慢性便秘无关。只有轻度抑郁与慢性便秘显著相关。
在对 NHANES 数据库的分析中，我们发现抑郁患者慢性腹泻和便秘的比例高于非抑郁患者；慢性腹泻与抑郁的关系更为密切。我们的研究结果为情绪与特定肠道习惯之间的关系提供了支持，考虑了一般美国人群中大量样本的多个协变量。
