Risse E K, van't Hof M A, Laurini R N, Vooijs P G
Diagn Cytopathol. 1985 Oct-Dec;1(4):286-91. doi: 10.1002/dc.2840010406.
From 1,488 patients, satisfactory sputum was available for cytologic diagnosis. Overall diagnoses were correct in 85.4% of patients, false negative in 193 patients (13.0%), and false positive in 24 patients (1.6%). In patients with a malignant lung process, cytologic diagnoses were correct in 228 patients (54.2%) and false negative in 193 patients (45.8%). In patients with primary lung cancer, the proportion of correct positive diagnoses increased from 0.47 to 0.87 with one to five sputum specimens examined. In patients with metastatic disease, the figures were 0.35 with one specimen examined and 0.38 with two and more sputum specimens. Cytologic typing accuracy was 67% for large-cell carcinomas, 73% for adenocarcinomas, 91% for small-cell lung cancers, and 98% for squamous-cell carcinomas. For the clinically most relevant groups of nonsmall-cell lung cancer and small-cell lung cancer, these figures were 99% and 91%, respectively.
从1488例患者中获取了可供细胞学诊断的合格痰液。总体诊断在85.4%的患者中是正确的，193例患者（13.0%）为假阴性，24例患者（1.6%）为假阳性。在患有肺部恶性病变的患者中，细胞学诊断在228例患者（54.2%）中是正确的，193例患者（45.8%）为假阴性。在原发性肺癌患者中，随着检查痰液标本数量从1份增加到5份，正确阳性诊断的比例从0.47增加到0.87。在转移性疾病患者中，检查1份标本时这一数字为0.35，检查2份及更多痰液标本时为0.38。大细胞癌的细胞学分型准确率为67%，腺癌为73%，小细胞肺癌为91%，鳞状细胞癌为98%。对于临床上最相关的非小细胞肺癌和小细胞肺癌组，这些数字分别为99%和91%。
