School of Environment and Natural Resources, Ohio State University, 2021 Coffey Rd, Columbus, OH, 43210, USA.
Institute for Population Research, Ohio State University, 060 Townshend Hall, 1885 Neil Ave Mall, Columbus, OH, 43210, USA.
Health Place. 2024 Sep;89:103330. doi: 10.1016/j.healthplace.2024.103330. Epub 2024 Aug 16.
There is increasing evidence indicating air pollution is an important factor influencing the aging brain. However, much of this work measures air pollution using particulate matter (PM). Yet we know that the chemical components of PM are not consistent across space or time. Rather, the possible chemical mixtures of PM vary and are therefore not reliably measuring the same thing across studies. In this study we attempt to disentangle the effects of the components of measured PM by using estimates of concurrent exposures of 415 industrial air toxics, as well as 44 neuro- and developmental toxics. Using bivariate latent curve models, we leverage individual level panel data from the bi-annual Health and Retirement Study to test how these exposures relate to cognitive score trajectories of respondents across the years 2002-2012. We find that more exposure to neurotoxics was associated with faster rate of cognitive decline by 1.09 points (p < 0.05).
越来越多的证据表明，空气污染是影响大脑衰老的一个重要因素。然而，这项工作的大部分都是用颗粒物（PM）来衡量空气污染的。然而，我们知道 PM 的化学成分在空间或时间上并不一致。相反，PM 的可能化学混合物是不同的，因此在不同的研究中并不能可靠地测量相同的东西。在这项研究中，我们试图通过使用同时暴露于 415 种工业空气毒素和 44 种神经和发育毒素的估计值来分解测量 PM 的成分的影响。我们利用来自两年一次的健康与退休研究的个人层面的面板数据，使用双变量潜在曲线模型来检验这些暴露与受访者在 2002 年至 2012 年期间的认知分数轨迹的关系。我们发现，接触更多的神经毒素与认知能力下降的速度加快有关，平均每年增加 1.09 分（p<0.05）。
