Kiani Pouria, Vatankhahan Hamid, Zare-Hoseinabadi Alireza, Ferdosi Felora, Ehtiati Sajad, Heidari Parasta, Dorostgou Zahra, Movahedpour Ahmad, Baktash Aria, Rajabivahid Mansour, Khatami Seyyed Hossein
Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Clin Chim Acta. 2025 Jan 1;564:119923. doi: 10.1016/j.cca.2024.119923. Epub 2024 Aug 15.
Breast cancer continues to be a significant contributor to global cancer deaths, particularly among women. This highlights the critical role of early detection and treatment in boosting survival rates. While conventional diagnostic methods like mammograms, biopsies, ultrasounds, and MRIs are valuable tools, limitations exist in terms of cost, invasiveness, and the requirement for specialized equipment and trained personnel. Recent shifts towards biosensor technologies offer a promising alternative for monitoring biological processes and providing accurate health diagnostics in a cost-effective, non-invasive manner. These biosensors are particularly advantageous for early detection of primary tumors, metastases, and recurrent diseases, contributing to more effective breast cancer management. The integration of biosensor technology into medical devices has led to the development of low-cost, adaptable, and efficient diagnostic tools. In this framework, electrochemical screening platforms have garnered significant attention due to their selectivity, affordability, and ease of result interpretation. The current review discusses various breast cancer biomarkers and the potential of electrochemical biosensors to revolutionize early cancer detection, making provision for new diagnostic platforms and personalized healthcare solutions.
乳腺癌仍然是全球癌症死亡的一个重要因素，尤其是在女性中。这凸显了早期检测和治疗对提高生存率的关键作用。虽然传统的诊断方法如乳房X光检查、活检、超声检查和核磁共振成像都是有价值的工具，但在成本、侵入性以及对专业设备和训练有素的人员的要求方面存在局限性。最近向生物传感器技术的转变为监测生物过程和以经济高效、非侵入性的方式提供准确的健康诊断提供了一个有前景的替代方案。这些生物传感器对于原发性肿瘤、转移瘤和复发性疾病的早期检测特别有利，有助于更有效地管理乳腺癌。将生物传感器技术集成到医疗设备中已导致开发出低成本、适应性强且高效的诊断工具。在此框架下，电化学筛查平台因其选择性、可承受性和结果解读的简便性而备受关注。本综述讨论了各种乳腺癌生物标志物以及电化学生物传感器在彻底改变早期癌症检测方面的潜力，为新的诊断平台和个性化医疗解决方案提供了条件。
