Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Clinical Research Development Unit (CRDU), Sayad Shirazi Hospital Golestan University of Medical Sciences, Gorgan, Iran.
Int J Biol Macromol. 2024 Oct;278(Pt 3):134778. doi: 10.1016/j.ijbiomac.2024.134778. Epub 2024 Aug 15.
Immunomodulatory therapies are beneficial strategies for the improvement of immune system function. Today, due to the increasing prevalence of immune disorders, cancer, and new viral diseases, there is a greater need to introduce immunomodulatory compounds with more efficiency and fewer side effects. Microbial derivatives are fertile and attractive grounds for discovering lots of novel compounds with various medical properties. The discovery of many natural compounds derived from bacterial sources, such as secondary metabolites with promising immunomodulating activities, represents the importance of this topic in drug discovery and emphasizes the necessity for a coherent source of study in this area. Considering this need, in this review, we aim to focus on the current information about the immunomodulatory effects of bacterial secondary metabolites and natural immunomodulators derived from microorganisms.
免疫调节疗法是改善免疫系统功能的有益策略。如今，由于免疫紊乱、癌症和新病毒疾病的发病率不断上升，人们越来越需要引入更有效、副作用更小的免疫调节化合物。微生物衍生物是发现具有各种医疗特性的新型化合物的肥沃而有吸引力的领域。许多源自细菌来源的天然化合物的发现，如具有有前途的免疫调节活性的次级代谢产物，代表了这一在药物发现领域的重要性，并强调了在该领域进行一致的研究的必要性。考虑到这一需求，在这篇综述中，我们旨在关注细菌次级代谢产物和微生物衍生天然免疫调节剂的免疫调节作用的最新信息。
