Department of Rheumatology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Department of Rheumatology and Immunology, Nanjing General Hospital of Nanjing Military Command, Nanjing, Jiangsu, China.
BMJ Open. 2024 Aug 17;14(8):e081015. doi: 10.1136/bmjopen-2023-081015.
Two-dimensional shear wave elastography (2D-SWE) is a non-invasive technique for the evaluation of Sjögren's disease (SjD). This study investigated the diagnostic accuracy of 2D-SWE in assessing major salivary gland involvement in SjD.
A systematic review and meta-analysis.
Data were obtained by searching PubMed, MEDLINE, EMBASE, Scopus, Cochrane library and CNKI from 1999 to 26 September 2022, which includes randomised clinical trial of 2D-SWE for the diagnosis of SjD.
(1) Patients (≥18 years old) diagnosed with SjD following the international classification in 2002 or 2016 American College of Rheumatology-European League Against Rheumatism classification criteria for SjD; (2) The purpose of this study was to evaluate the diagnostic value of 2D-SWE in SjD; (3) The evaluation parameters for the diagnosis of SjD can be extracted or indirectly obtained in this article, including sensitivity, specificity, true positive, false positive, false negative, true negative, diagnostic point (Young's modulus) and other data.
Four authors independently screened and assessed the literature and extracted the data. RevMan V.5.3 and StataMP V.18 software were used for quality assessment and meta-analysis.
We included 8 studies with a total of 912 cases, including 509 patients with SjD. The high-risk bias in the quality evaluation focused on patient selection and index test. The pooled sensitivity, specificity and summary area under the curve of 2D-SWE were 0.75 (95% CI 0.62 to 0.84), 0.89 (95% CI 0.80 to 0.94) and 0.90 (95% CI 0.87 to 0.92), respectively.
2D-SWE has an acceptable diagnostic accuracy for SjD patients and is an effective tool for auxiliary diagnosis of SjD.
CRD42022365766.
二维剪切波弹性成像（2D-SWE）是一种用于评估干燥综合征（SjD）的非侵入性技术。本研究旨在探讨 2D-SWE 在评估 SjD 主要唾液腺受累方面的诊断准确性。
系统评价和荟萃分析。
从 1999 年至 2022 年 9 月 26 日，通过检索 PubMed、MEDLINE、EMBASE、Scopus、Cochrane 图书馆和中国知网（CNKI）等数据库，获取关于 2D-SWE 用于 SjD 诊断的随机临床试验数据。
（1）符合 2002 年国际分类或 2016 年美国风湿病学会-欧洲抗风湿病联盟 SjD 分类标准诊断为 SjD 的患者（≥18 岁）；（2）本研究旨在评估 2D-SWE 在 SjD 中的诊断价值；（3）本文可提取或间接获得 SjD 诊断的评估参数，包括敏感度、特异度、真阳性、假阳性、假阴性、真阴性、诊断点（杨氏模量）和其他数据。
四位作者独立筛选和评估文献并提取数据。采用 RevMan V.5.3 和 StataMP V.18 软件进行质量评估和荟萃分析。
我们纳入了 8 项研究，共 912 例患者，其中 509 例为 SjD 患者。质量评估中的高风险偏倚主要集中在患者选择和指标检测方面。2D-SWE 的汇总敏感度、特异度和曲线下面积分别为 0.75（95%CI 0.62 至 0.84）、0.89（95%CI 0.80 至 0.94）和 0.90（95%CI 0.87 至 0.92）。
2D-SWE 对 SjD 患者具有可接受的诊断准确性，是 SjD 辅助诊断的有效工具。
CRD42022365766。
