甲状腺原发性神经鞘瘤：病例特征分析及文献复习。
Primary schwannoma of the thyroid gland: analysis of case characteristics and review of the literature.
机构信息
Department of General Surgery, The First People's Hospital of Yuhang District, Hangzhou, Zhejiang, 311100, China.
Department of Thyroid Breast Surgery, Yanbian University Hospital, Yanbian, Jilin, 133000, China.
出版信息
BMC Surg. 2024 Aug 17;24(1):234. doi: 10.1186/s12893-024-02523-y.
BACKGROUND
To improve the characteristics of primary thyroid schwannomas (PTS) and to provide reference basis for clinical diagnosis and treatment.
METHODS
PubMed was searched for case reports of PTS up to December 2022 using the search terms "Thyroid nerve sheath tumor" or "Thyroid schwannoma" or "Thyroid Neurilemmoma", respectively. 34 cases were screened.
RESULTS
PTS can occur at any age, nodules averaged 3.9 cm. The most common symptoms were voice change and dysphagia. Fine needle aspiration cytology showing spindle-shaped cells should be considered for schwannoma. Most cases underwent thyroid lobectomy or nodule removal with a good prognosis. Tissue types with both Antoni A and Antoni B features are common. Positive immunohistochemical staining for S-100 protein, CD34 and waveform proteins helped confirm the diagnosis.
CONCLUSIONS
Positive immunohistochemistry for S-100 and wave proteins helps confirm the diagnosis. Preoperative diagnosis is challenging, but pathology and immunohistochemical staining are the gold standard for diagnosis. The first choice of treatment is surgical resection of the nodules, the prognosis is good.
背景
为了提高原发性甲状腺神经鞘瘤（PTS）的特征，并为临床诊断和治疗提供参考依据。
方法
检索 PubMed 截至 2022 年 12 月，使用的检索词分别为“甲状腺神经鞘瘤”或“甲状腺 schwannoma”或“甲状腺神经纤维瘤”，共筛选出 34 例病例报告。
结果
PTS 可发生于任何年龄，结节平均直径为 3.9cm。最常见的症状是声音改变和吞咽困难。细针穿刺细胞学显示梭形细胞时应考虑 schwannoma。大多数患者行甲状腺叶切除术或结节切除术，预后良好。常见的组织类型既有 Antoni A 又有 Antoni B 特征。S-100 蛋白、CD34 和波形蛋白的免疫组织化学染色阳性有助于确诊。
结论
S-100 和波形蛋白的免疫组织化学染色有助于确诊。术前诊断具有挑战性，但病理和免疫组织化学染色是诊断的金标准。治疗的首选方法是结节切除术，预后良好。
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