Medical College of Soochow University, Suzhou, 215123, Jiangsu, China.
Department of Anesthesiology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, China.
Sci Rep. 2024 Aug 17;14(1):19085. doi: 10.1038/s41598-024-69699-4.
Systemic inflammatory response index (SIRI) has been proven to be associated with the prognosis of coronary artery disease and many other diseases. However, the relationship between SIRI and acute traumatic spinal cord injury (tSCI) has rarely been evaluated. The study aims to assess the prognostic value of SIRI for clinical outcomes in individuals with acute tSCI. A total of 190 patients admitted within eight hours after tSCI between January 2021 and April 2023 were enrolled in our study. Logistic regression analysis was used to analyze the association between SIRI and American Spinal Injury Association Impairment Scale (AIS) grade at admission and discharge, as well as neurological improvement in tSCI patients, and receiver operating characteristic (ROC) analysis was performed to assess the discriminative ability of SIRI in predicting AIS grade at discharge. After adjusting for confounding factors, SIRI positively correlated with the AIS grade (A to C) at admission and discharge, and negatively correlated with neurological improvement. The area under the curve values in ROC analysis was 0.725 (95% CI 0.647, 0.803). The study suggests that SIRI is significantly associated with an increased risk of poor clinical outcome at discharge in tSCI patients and has a certain discriminative value.
全身炎症反应指数 (SIRI) 已被证明与冠状动脉疾病和许多其他疾病的预后相关。然而，SIRI 与急性创伤性脊髓损伤 (tSCI) 之间的关系很少被评估。本研究旨在评估 SIRI 对急性 tSCI 患者临床结局的预后价值。2021 年 1 月至 2023 年 4 月期间，共纳入了 190 例 tSCI 后 8 小时内入院的患者。使用逻辑回归分析来分析 SIRI 与入院和出院时的美国脊髓损伤协会损伤分级（AIS）以及 tSCI 患者的神经功能改善之间的关联，并进行受试者工作特征（ROC）分析以评估 SIRI 在预测出院时 AIS 分级方面的判别能力。在调整混杂因素后，SIRI 与入院和出院时的 AIS 分级（A 至 C）呈正相关，与神经功能改善呈负相关。ROC 分析的曲线下面积值为 0.725（95%CI 0.647，0.803）。该研究表明，SIRI 与 tSCI 患者出院时不良临床结局的风险增加显著相关，具有一定的判别价值。
