Department of Pediatrics, University of Health Sciences, Kartal Dr. Lütfi Kırdar City Hospital, Istanbul, Türkiye.
Department of Pediatric Neurology, University of Health Sciences, Kartal Dr. Lütfi Kırdar City Hospital, Istanbul, Türkiye.
Ital J Pediatr. 2024 Aug 17;50(1):150. doi: 10.1186/s13052-024-01722-w.
Childhood obesity has become a major global health problem. Obesity is associated with major health problems, such as diabetes, hypertension, dyslipidemia, cardiovascular disease. Obesity is also considered a risk factor for Pseudotumor cerebri (PTC). The present study aimed to investigate the relationship between body mass index (BMI), and cerebrospinal fluid (CSF) pressure in patients with pseudotumor cerebri.
A total of 48 children diagnosed with PTC, who were aged < 18 years and followed up in the pediatric clinic were included in the retrospective study. National BMI percentile curves were used for reference. We investigated statistically the relationship between BMI, clinical and laboratory results, and CSF pressure in patients.
Of total patients 27 were female (56.25%) and 21 were male (43.75%). With regard to the BMI percentile, 20 (41.67%) were overweight or obese. CSF pressure was higher in overweight and obese patients compared to children with BMI in normal ranges (p < 0.05). A statistically significant positive correlation was also observed between BMI and CSF pressure values and between monocyte and CSF values (p < 0.05).
The results of the present study indicate a direct relationship between CSF pressure and BMI in children with PTC. Appropriate diet, exercise, and medical treatment in overweight and obese children can make a significant contribution to the treatment of PTC. Additionally, a significant correlation was observed between CSF pressure and monocyte levels.
儿童肥胖已成为一个主要的全球健康问题。肥胖与多种健康问题相关，如糖尿病、高血压、血脂异常、心血管疾病。肥胖也被认为是假性脑瘤（PTC）的一个危险因素。本研究旨在探讨肥胖症与假性脑瘤患者的脑脊液（CSF）压力之间的关系。
本回顾性研究共纳入 48 名在儿科诊所就诊的被诊断为 PTC 的儿童患者，年龄均小于 18 岁。我们参考了国家 BMI 百分位数曲线。我们统计分析了患者的 BMI、临床和实验室结果与 CSF 压力之间的关系。
在总共 48 名患者中，27 名（56.25%）为女性，21 名（43.75%）为男性。就 BMI 百分位而言，20 名（41.67%）超重或肥胖。与 BMI 正常范围的儿童相比，超重和肥胖患者的 CSF 压力更高（p<0.05）。BMI 与 CSF 压力值之间以及单核细胞与 CSF 值之间也存在显著的正相关关系（p<0.05）。
本研究结果表明，PTC 儿童的 CSF 压力与 BMI 之间存在直接关系。超重和肥胖儿童的适当饮食、运动和医疗治疗可以对 PTC 的治疗做出重大贡献。此外，还观察到 CSF 压力与单核细胞水平之间存在显著相关性。
