Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Departamento de Neurologia, São Paulo SP, Brazil.
Arq Neuropsiquiatr. 2022 May;80(5 Suppl 1):204-213. doi: 10.1590/0004-282X-ANP-2022-S106.
Obesity and headache disorders are two very common conditions in the general population that have been increasing in incidence over the last decades. Recent studies have shown a significant relationship between obesity and headaches, particularly migraine, with an important role in whether the disease is chronic. On the other hand, no such association was found with tension-type headaches. Studies showing an overlapping of hunger-control pathways and those involved in the pathophysiology of migraine may justify the close association between obesity and migraine. Moreover, a secondary headache for which obesity is a strong risk factor is idiopathic Intracranial Hypertension (pseudotumor cerebri), with several studies showing the impact of weight reduction/bariatric surgery in the treatment of the disease. In conclusion, since obesity is a modifiable risk factor, it is important for physicians treating patients with headaches, and particularly migraine, to be aware of the association between these two disorders.
肥胖症和头痛障碍是两种在普通人群中非常常见的疾病，近年来其发病率一直在上升。最近的研究表明，肥胖症与头痛之间存在显著的相关性，尤其是偏头痛，而偏头痛是否为慢性疾病在其中起着重要作用。另一方面，紧张型头痛与肥胖症之间则没有这种关联。研究表明，饥饿控制途径与偏头痛病理生理学中涉及的途径存在重叠，这可能解释了肥胖症与偏头痛之间的密切关联。此外，肥胖症是一种强烈的危险因素，可导致继发性头痛，即特发性颅内高压（假性脑瘤），多项研究表明减轻体重/减肥手术对该疾病的治疗效果。总之，由于肥胖症是一种可改变的危险因素，因此对于治疗头痛患者，特别是偏头痛患者的医生来说，了解这两种疾病之间的关联非常重要。
