Goi H, Watanabe T, Miyauchi K, Kazuno Y, Inouye S
Drugs Exp Clin Res. 1985;11(11):771-80.
The bactericidal and morphological effects under drug-decreasing conditions of cefminox (MT-141), cefoxitin, cefmetazole, cefotetan and latamoxef were compared on Klebsiella pneumoniae PCl-602, Escherichia coli No. 29 and Serratia marcescens No. 1 cells. A new drug-decreasing method was developed by the use of an antibiotic removal device. Cefminox displayed an earlier onset and a higher rate of bactericidal action than the other cephamycins against the test organisms, although the minimum inhibitory concentrations of cefminox were similar to or higher than those of the other drugs. Morphologically, cefminox caused rapid lysis of the cells without filamentation, whereas the reference cephamycins caused mainly elongation of the cells under the test conditions. Frequent formation of multiple bulges on cells exposed to cefminox was observed in an isotonic medium.
比较了头孢米诺（MT - 141）、头孢西丁、头孢美唑、头孢替坦和拉氧头孢在药物减量条件下对肺炎克雷伯菌PCl - 602、大肠杆菌29号和粘质沙雷氏菌1号细胞的杀菌和形态学效应。通过使用抗生素去除装置开发了一种新的药物减量方法。尽管头孢米诺的最低抑菌浓度与其他药物相似或更高，但与其他头孢霉素相比，头孢米诺对受试菌表现出更早的起效时间和更高的杀菌作用速率。在形态学上，头孢米诺可使细胞迅速裂解而不形成丝状体，而在测试条件下，对照头孢霉素主要导致细胞伸长。在等渗培养基中观察到，暴露于头孢米诺的细胞频繁形成多个凸起。
