Watanabe S, Omoto S
Research & Development Planning, Meiji Seika Kaisha, Ltd., Tokyo, Japan.
Drugs Exp Clin Res. 1990;16(9):461-7.
Cefminox is a new cephamycin antibiotic possessing a D-amino acid moiety derived from D-cysteine at the C-7B side chain. Cefminox is active against a wide range of bacteria, especially Gram-negative and anaerobic bacteria. Cefminox shows excellent in vivo efficacy (ED50) which is higher than would be expected from its in vitro activity (MIC). Moreover, cefminox possesses more potent activity in suppression of bacterial regrowth than other cephems. These phenomena are surmised to be caused by strong bactericidal activity which is attributed to a dual action mechanism.
氨曲南是一种新型头孢菌素抗生素，在C-7B侧链上具有一个源自D-半胱氨酸的D-氨基酸部分。氨曲南对多种细菌具有活性，尤其是革兰氏阴性菌和厌氧菌。氨曲南在体内显示出优异的疗效（ED50），高于根据其体外活性（MIC）预期的疗效。此外，氨曲南在抑制细菌再生长方面比其他头孢菌素具有更强的活性。这些现象据推测是由归因于双重作用机制的强大杀菌活性引起的。
