College of Bioresources Chemical and Materials Engineering, Shaanxi Province Key Laboratory of Papermaking Technology and Specialty Paper Development, Shaanxi University of Science & Technology, Xi'an, Shaanxi, 710021, China; Limerick Pulp & Paper Centre & Department of Chemical Engineering, University of New Brunswick, Fredericton, NB, E3B 5A3, Canada.
College of Bioresources Chemical and Materials Engineering, Shaanxi Province Key Laboratory of Papermaking Technology and Specialty Paper Development, Shaanxi University of Science & Technology, Xi'an, Shaanxi, 710021, China.
Anal Chim Acta. 2024 Sep 8;1321:342877. doi: 10.1016/j.aca.2024.342877. Epub 2024 Jun 19.
The rapid emergence of microfluidic paper-based devices as point-of-care testing (POCT) tools for early disease diagnosis and health monitoring, particularly in resource-limited areas, holds immense potential for enhancing healthcare accessibility. Leveraging the numerous advantages of paper, such as capillary-driven flow, porous structure, hydrophilic functional groups, biodegradability, cost-effectiveness, and flexibility, it has become a pivotal choice for microfluidic substrates. The repertoire of microfluidic paper-based devices includes one-dimensional lateral flow assays (1D LFAs), two-dimensional microfluidic paper-based analytical devices (2D μPADs), and three-dimensional (3D) μPADs. In this comprehensive review, we provide and examine crucial information related to paper substrates, design strategies, and detection methods in multi-dimensional microfluidic paper-based devices. We also investigate potential applications of microfluidic paper-based devices for detecting viruses, metabolites and hormones in non-invasive samples such as human saliva, sweat and urine. Additionally, we delve into capillary-driven flow alternative theoretical models of fluids within the paper to provide guidance. Finally, we critically examine the potential for future developments and address challenges for multi-dimensional microfluidic paper-based devices in advancing noninvasive early diagnosis and health monitoring. This article showcases their transformative impact on healthcare, paving the way for enhanced medical services worldwide.
微流控纸基器件作为即时检测（POCT）工具在疾病早期诊断和健康监测中的应用迅速崛起，尤其是在资源有限的地区，为提高医疗保健的可及性提供了巨大的潜力。利用纸的诸多优势，如毛细驱动流、多孔结构、亲水性官能团、生物降解性、成本效益和灵活性，它已成为微流控基板的重要选择。微流控纸基器件的种类包括一维横向流动分析（1D LFAs）、二维微流控纸基分析器件（2D μPADs）和三维（3D）μPADs。在这篇全面的综述中，我们提供并检查了与多维微流控纸基器件中的纸基、设计策略和检测方法相关的关键信息。我们还研究了微流控纸基器件在检测非侵入性样本（如人唾液、汗液和尿液）中的病毒、代谢物和激素方面的潜在应用。此外，我们深入探讨了纸内流体的毛细驱动流替代理论模型，为其提供了指导。最后，我们批判性地研究了多维微流控纸基器件在推进非侵入性早期诊断和健康监测方面的未来发展潜力和挑战。本文展示了它们在医疗保健领域的变革性影响，为全球医疗服务的提升铺平了道路。
