Department of Metabolism, Endocrinology and Molecular Medicine, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Department of Premier Preventive Medicine, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Diab Vasc Dis Res. 2024 Jul-Aug;21(4):14791641241278362. doi: 10.1177/14791641241278362.
Syndecan (SDC)-1 is a transmembrane heparan sulfate proteoglycan and is a major component of endothelial glycocalyx (EG). This study aimed to investigate the association of serum SDC-1 concentration as a marker of EG degradation with albuminuria in type 2 diabetes.
We included 370 patients with type 2 diabetes and 219 individuals with no diabetes. The individuals with estimate glomerular filtration rate <30 mL/min/1.73 m were excluded.
Serum SDC-1 concentration was higher in type 2 diabetes than in no diabetes. The presence of diabetes was independently associated with log [SDC-1] in multivariate analysis. In type 2 diabetes, serum SDC-1 concentration was correlated with log [urinary albumin-to-creatinine ratio (ACR)]. Moreover, log [SDC-1] was an independent determinant of log [ACR] after adjustment for known risk factors of albuminuria.
Serum SDC-1 concentration was higher in patients with type 2 diabetes compared to individuals with no diabetes and an independent determinant of ACR. This study implicates the role of the EG degradation in albuminuria in type 2 diabetes.
硫酸乙酰肝素蛋白聚糖-1（SDC-1）是一种跨膜硫酸乙酰肝素蛋白聚糖，是血管内皮糖萼（EG）的主要组成部分。本研究旨在探讨作为 EG 降解标志物的血清 SDC-1 浓度与 2 型糖尿病患者蛋白尿之间的关系。
我们纳入了 370 例 2 型糖尿病患者和 219 例无糖尿病患者。排除估计肾小球滤过率 <30 mL/min/1.73 m 的个体。
与无糖尿病患者相比，2 型糖尿病患者的血清 SDC-1 浓度更高。在多变量分析中，糖尿病的存在与 log [SDC-1] 独立相关。在 2 型糖尿病患者中，血清 SDC-1 浓度与 log [尿白蛋白/肌酐比值（ACR）] 相关。此外，在调整蛋白尿的已知危险因素后，log [SDC-1] 是 log [ACR] 的独立决定因素。
与无糖尿病患者相比，2 型糖尿病患者的血清 SDC-1 浓度更高，是 ACR 的独立决定因素。本研究提示 EG 降解在 2 型糖尿病患者蛋白尿中的作用。
