Miyamoto Shoko, Kakutani Yoshinori, Morioka Tomoaki, Yamazaki Yuko, Ochi Akinobu, Fukumoto Shinya, Shoji Tetsuo, Emoto Masanori
Department of Metabolism, Endocrinology and Molecular Medicine, Osaka Metropolitan University Graduate School of Medicine.
Department of Premier Preventive Medicine, Osaka Metropolitan University Graduate School of Medicine.
J Atheroscler Thromb. 2025 Jul 26. doi: 10.5551/jat.65623.
Serum syndecan-1 (SDC-1) concentration is a biomarker for endothelial glycocalyx (EG) degradation, which is elevated in type 2 diabetes (T2D). EG degradation is an early step in vascular endothelial dysfunction. This study investigated the association between serum SDC-1 concentration and visceral fat accumulation, which is closely related to vascular endothelial dysfunction, in people with and without T2D.
This was a cross-sectional study with two independent groups, one including 219 individuals without diabetes (ND) and the other including 203 individuals with T2D. Visceral fat accumulation was assessed as the visceral fat area (VFA) using computed tomography (CT) in ND or dual bioelectrical impedance analysis (BIA) in T2D. Multivariate analyses were performed for ND and T2D to assess the association between VFA and serum SDC-1 concentrations.
The medians of serum SDC-1 concentration were 16.0 ng/mL and 26.5 ng/mL in ND and T2D, respectively. In the univariate analysis, both CT-VFA in the ND group and BIA-VFA in the T2D group were positively correlated with serum SDC-1 concentration. Moreover, the association between VFAs and serum SDC-1 concentration was independent of other covariates in multivariate analysis for each group. However, neither the body mass index nor subcutaneous fat area were associated with serum SDC-1 concentrations in either group.
CT-VFA and BIA-VFA were independently associated with serum SDC-1 concentrations. Our findings suggest that visceral fat accumulation is involved in the degradation of EG irrespective of the presence of T2D.
血清 syndecan-1（SDC-1）浓度是内皮糖萼（EG）降解的生物标志物，在2型糖尿病（T2D）中升高。EG降解是血管内皮功能障碍的早期步骤。本研究调查了有无T2D人群中血清SDC-1浓度与内脏脂肪堆积之间的关联，内脏脂肪堆积与血管内皮功能障碍密切相关。
这是一项横断面研究，有两个独立组，一组包括219名无糖尿病个体（ND），另一组包括203名T2D个体。在ND组中使用计算机断层扫描（CT）评估内脏脂肪堆积，将其作为内脏脂肪面积（VFA）；在T2D组中使用双频生物电阻抗分析（BIA）评估。对ND组和T2D组进行多变量分析，以评估VFA与血清SDC-1浓度之间的关联。
ND组和T2D组血清SDC-1浓度的中位数分别为16.0 ng/mL和26.5 ng/mL。在单变量分析中，ND组的CT-VFA和T2D组的BIA-VFA均与血清SDC-1浓度呈正相关。此外，在每组的多变量分析中，VFA与血清SDC-1浓度之间的关联独立于其他协变量。然而，两组中体重指数和皮下脂肪面积均与血清SDC-1浓度无关。
CT-VFA和BIA-VFA与血清SDC-1浓度独立相关。我们的研究结果表明，无论是否存在T2D，内脏脂肪堆积都参与了EG的降解。
