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儿童合并感染情况下快速诊断肺炎链球菌的有效方法——病例报告

Efficient Method for Rapid Diagnosis of Streptococcal Pneumoniae in the Context of Co-Infection in Children-Case Report.

作者信息

Stavar-Matei Loredana, Mihailov Oana-Mariana, Crestez Alexandra-Mihaela, Alexandru Anamaria Madalina, Popescu Cristina-Mihaela, Nechita Aurel

机构信息

Dunarea de Jos" University of Galati, Faculty of Medicine and Pharmacy, Galati,Romania.

Sf. Ioan" Children's Clinical Emergency Hospital, Galati, Romania.

出版信息

Pediatric Health Med Ther. 2024 Aug 13;15:273-278. doi: 10.2147/PHMT.S467351. eCollection 2024.

DOI:10.2147/PHMT.S467351
PMID:39155991
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11330237/
Abstract

BACKGROUND

Bacterial pneumonia caused by continues to be one of the most common medical conditions in the pediatric population under 5 years of age, sometimes requiring prolonged hospitalizations and high costs. The time period (3 to 7 days) from the collection of biological samples (ie nasal exudate, pharyngeal exudate, sputum, blood culture and various secretions) to the arrival of the results has been a much discussed issue. Thus, the use of a rapid diagnostic test for urinary antigen, which is easy to use, may lead after the result is known to a targeted therapeutic management and thus to a favorable prognosis of the disease for the patient.

METHODS

This case report presents the case of a 4 years and 5 months old patient diagnosed with invasive pneumococcal-associated pneumococcal infection in the context of SARS-COV2 infection.

RESULTS

The clinical course was slowly favorable with complications that required a long hospitalization.

CONCLUSION

In conclusion, some rapid diagnostic techniques, clinician judgment and some prevention methods, such as vaccination, can improve a patient's quality of life. One prospect for the future would be the development of new vaccines covering other aggressive serotypes.

摘要

背景

由[病原体名称未给出]引起的细菌性肺炎仍然是5岁以下儿童中最常见的病症之一,有时需要长期住院治疗且费用高昂。从采集生物样本(即鼻分泌物、咽分泌物、痰液、血培养及各种分泌物)到结果出来的这段时间(3至7天)一直是备受讨论的问题。因此,使用易于操作的[病原体名称未给出]尿抗原快速诊断检测,在得知结果后可能会进行有针对性的治疗管理,从而使患者疾病预后良好。

方法

本病例报告介绍了一名4岁5个月大的患者,在感染SARS - COV2的情况下被诊断为侵袭性肺炎球菌相关肺炎球菌感染。

结果

临床病程缓慢好转,但出现了并发症,需要长期住院。

结论

总之,一些快速诊断技术、临床医生的判断以及一些预防方法,如接种疫苗,可以提高患者的生活质量。未来的一个展望是研发覆盖其他侵袭性[病原体名称未给出]血清型的新型疫苗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a7d/11330237/6154391bb977/PHMT-15-273-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a7d/11330237/8fd71d9e9287/PHMT-15-273-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a7d/11330237/da5442520928/PHMT-15-273-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a7d/11330237/6154391bb977/PHMT-15-273-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a7d/11330237/8fd71d9e9287/PHMT-15-273-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a7d/11330237/da5442520928/PHMT-15-273-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a7d/11330237/6154391bb977/PHMT-15-273-g0003.jpg

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本文引用的文献

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Front Cell Infect Microbiol. 2021 Mar 22;11:643326. doi: 10.3389/fcimb.2021.643326. eCollection 2021.
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BMC Infect Dis. 2020 Dec 9;20(1):940. doi: 10.1186/s12879-020-05674-4.
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Burden of Streptococcus pneumoniae and Haemophilus influenzae type b disease in children in the era of conjugate vaccines: global, regional, and national estimates for 2000-15.在结合疫苗时代儿童感染肺炎链球菌和乙型流感嗜血杆菌疾病的负担:2000-2015 年全球、区域和国家估计数。
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Hum Vaccin Immunother. 2017 Jun 3;13(6):1-12. doi: 10.1080/21645515.2016.1263409. Epub 2016 Dec 20.
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Cost Effectiveness of Pneumococcal Vaccination in Children in Low- and Middle-Income Countries: A Systematic Review.低收入和中等收入国家儿童肺炎球菌疫苗接种的成本效益:一项系统评价
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Prospective, randomised study to compare empirical treatment versus targeted treatment on the basis of the urine antigen results in hospitalised patients with community-acquired pneumonia.前瞻性、随机研究,旨在比较基于尿抗原检测结果的经验性治疗与靶向治疗对住院社区获得性肺炎患者的疗效。
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