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异基因干细胞移植患者的特发性非典型失神癫痫持续状态

Unprovoked Atypical Absence Status Epilepticus in a Patient With Allogeneic Stem Cell Transplantation.

作者信息

Banerjee Sumona, Chaudhry Maaria, Brewer Jonathan, Chen Yongzhen, Khasiyev Farid, Soudagar Turkey Momina

机构信息

Neurology, Saint Louis University School of Medicine, Saint Louis, USA.

出版信息

Cureus. 2024 Jul 18;16(7):e64842. doi: 10.7759/cureus.64842. eCollection 2024 Jul.

DOI:10.7759/cureus.64842
PMID:39156368
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11330277/
Abstract

Absence status epilepticus (ASE) is a rare but treatable condition, and when present in older adults, it can be misinterpreted as encephalopathy or behavioral changes. Our case discusses a 63-year-old patient with myelofibrosis and allogeneic stem cell transplant with late-onset de novo status epilepticus. This case report adds to the rare body of literature discussing de novo ASE whose clinical presentation can be indistinguishable from other encephalopathic or behavioral conditions. Moreover, its occurrence during oncologic treatment warrants clinicians to be on the lookout for similar presentations and encourages future reports of this condition in association with similar therapies. This case report provides value to providers treating patients with similar oncologic therapies and highlights the need for ASE to be further studied as it is a possible rare complication of allogeneic transplantation of stem cells.

摘要

失神癫痫持续状态(ASE)是一种罕见但可治疗的病症,在老年人中出现时,可能会被误诊为脑病或行为改变。我们的病例讨论了一名63岁患有骨髓纤维化并接受异基因干细胞移植的患者,该患者出现了迟发性新发癫痫持续状态。本病例报告补充了关于新发ASE的罕见文献,其临床表现可能与其他脑病或行为病症难以区分。此外,它在肿瘤治疗期间的发生促使临床医生留意类似表现,并鼓励未来报告这种与类似疗法相关的病症。本病例报告为治疗接受类似肿瘤疗法患者的医疗人员提供了参考价值,并强调了由于ASE可能是异基因干细胞移植的一种罕见并发症,因此有必要对其进行进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d0d/11330277/dc58aca95238/cureus-0016-00000064842-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d0d/11330277/dc58aca95238/cureus-0016-00000064842-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d0d/11330277/dc58aca95238/cureus-0016-00000064842-i01.jpg

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本文引用的文献

1
Extreme late onset of genetic generalized epilepsy in older adults and the elderly: A cohort study and literature review.老年期及老年后起病的遗传全面性癫痫的极晚发病:一项队列研究和文献复习。
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Epileptic Seizures After Allogeneic Hematopoietic Stem Cell Transplantation.
异基因造血干细胞移植后的癫痫发作
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Seizures after transplantation.移植术后发作。
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Epilepsia. 2015 Oct;56(10):1515-23. doi: 10.1111/epi.13121. Epub 2015 Sep 4.
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Seizures and epilepsy: an overview for neuroscientists.癫痫发作与癫痫:神经科学家概述
Cold Spring Harb Perspect Med. 2015 Jun 1;5(6):a022426. doi: 10.1101/cshperspect.a022426.
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The syndrome of absence status epilepsy: review of the literature.失神性癫痫持续状态综合征:文献综述
Epilepsy Res Treat. 2014;2014:624309. doi: 10.1155/2014/624309. Epub 2014 Feb 10.
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'De novo' absence status of late onset: report of 11 cases.
Neurology. 1992 Jan;42(1):104-10. doi: 10.1212/wnl.42.1.104.