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俄罗斯老年人群中白内障、白内障手术及术后结果的患病率和相关因素:乌拉尔高龄研究

Prevalence and Associated Factors of Cataract, Cataract Surgery and Postoperative Outcome in an Old Population in Russia: The Ural Very Old Study.

作者信息

Bikbov Mukharram M, Kazakbaeva Gyulli M, Panda-Jonas Songhomitra, Lakupova Ellina M, Fakhretdinova Albina A, Tuliakova Azaliia M, Jonas Jost B

机构信息

Ufa Eye Research Institute, Bashkir State Medical University, Ufa, Russia.

Department of Ophthalmology, University Hospital Heidelberg, Heidelberg, Germany.

出版信息

Ophthalmol Sci. 2024 May 7;4(6):100545. doi: 10.1016/j.xops.2024.100545. eCollection 2024 Nov-Dec.

Abstract

PURPOSE

To assess prevalence of cataract and cataract surgery in a very old population in Russia.

DESIGN

Population-based study.

PARTICIPANTS

The Ural Very Old Study included 1526 (81.1%) participants of 1882 eligible individuals aged >85 years.

METHODS

Series of ophthalmological examinations.

MAIN OUTCOME MEASURES

Prevalence of cataract and cataract surgery.

RESULTS

The study included 1163 (76.3%) individuals with lens information. Cataract surgery had been performed in 469 right eyes (41.0%; 95% confidence interval [CI]: 38.1-43.9) (92.1% with posterior chamber intraocular lens [IOL]; 4.7% with multifocal IOL) and 479 left eyes (41.6%; 95% CI: 38.7-44.4) (92.7% with posterior chamber IOL; 4.2% with multifocal IOL). Cataract surgery had been performed in at least one eye for 610 (52.5%) individuals. Higher prevalence of previous cataract surgery correlated (multivariable analysis) with lower IOP (OR: 0.92; 95% CI: 0.88-0.95), glaucomatous optic nerve damage stage (OR: 1.20; 95% CI: 1.05-1.36), and better visual acuity (OR: 0.67; 95% CI: 0.51-0.89). Postoperative best corrected visual acuity was reduced to moderate-to-severe vision impairment (MSVI) in 202 eyes (44.6%; 95% CI: 40.0-49.2) and to blindness in 53 eyes (11.7%; 95% CI: 8.7-14.7). Causes of postoperative MSVI were age-related macular degeneration (AMD) (34.2%), glaucoma (13.9%), and secondary cataract (5.4%). Causes for blindness were AMD (24.5%), glaucoma (18.9%), corneal opacifications (15.8%) and myopic macular degeneration (11.3%). Yttrium Aluminum Garnet-laser capsulotomy had been performed in 6 (1.3%) of 469 right eyes and 12 (2.5%) of 479 left eyes. Prevalence of nuclear cataract and cortical cataract was 604/671 (90.0% in phakic eyes; 51.9% in the whole study population) and 97.9% eyes (48.4% in total study population). Cataract caused bilateral MSVI and blindness in 28.2% (95% CI: 25.6-30) and 2.9% (95% CI: 1.9-3.9), respectively, of all study participants.

CONCLUSIONS

Despite a relatively high prevalence of cataract surgery, this multiethnic cohort >85 years of aged from Russia showed a high prevalence of cataract-related MSVI and blindness. Main causes for postoperative MSVI (prevalence: 44.6%) and blindness (prevalence: 11.7%) were AMD, glaucoma, corneal opacifications, and myopic macular degeneration. Almost all individuals aged 85+ years need cataract surgery, despite limited chance of postoperative good vision.

FINANCIAL DISCLOSURES

The author(s) have no proprietary or commercial interest in any materials discussed in this article.

摘要

目的

评估俄罗斯高龄人群中白内障及白内障手术的患病率。

设计

基于人群的研究。

参与者

乌拉尔高龄研究纳入了1882名年龄大于85岁的符合条件个体中的1526名(81.1%)。

方法

一系列眼科检查。

主要观察指标

白内障及白内障手术的患病率。

结果

该研究纳入了1163名(76.3%)有晶状体信息的个体。469只右眼(41.0%;95%置信区间[CI]:38.1 - 43.9)进行了白内障手术(92.1%植入后房型人工晶状体[IOL];4.7%植入多焦点IOL),479只左眼(41.6%;95% CI:38.7 - 44.4)进行了白内障手术(92.7%植入后房型IOL;4.2%植入多焦点IOL)。610名(52.5%)个体至少一只眼进行了白内障手术。既往白内障手术较高的患病率与较低的眼压(比值比[OR]:0.92;95% CI:0.88 - 0.95)、青光眼性视神经损害分期(OR:1.20;95% CI:1.05 - 1.36)以及较好的视力(OR:0.67;95% CI:0.51 - 0.89)相关(多变量分析)。术后最佳矫正视力降至中度至重度视力损害(MSVI)的有202只眼(44.6%;95% CI:40.0 - 49.2),降至失明的有53只眼(11.7%;95% CI:8.7 - 14.7)。术后MSVI的原因是年龄相关性黄斑变性(AMD)(34.2%)、青光眼(13.9%)和后发性白内障(5.4%)。失明的原因是AMD(24.5%)、青光眼(18.9%)、角膜混浊(15.8%)和近视性黄斑变性(11.3%)。469只右眼中6只(1.3%)、479只左眼中12只(2.5%)进行了钇铝石榴石激光晶状体囊切开术。核性白内障和皮质性白内障的患病率分别为604/671(有晶状体眼为90.0%;整个研究人群为51.9%)和97.9%的眼(整个研究人群为48.4%)。白内障导致所有研究参与者中分别有28.2%(95% CI:25.6 - 30)和2.9%(95% CI:1.9 - 3.9)出现双侧MSVI和失明。

结论

尽管白内障手术患病率相对较高,但这个来自俄罗斯的85岁以上多民族队列显示白内障相关的MSVI和失明患病率很高。术后MSVI(患病率:44.6%)和失明(患病率:11.7%)的主要原因是AMD、青光眼、角膜混浊和近视性黄斑变性。尽管术后视力良好的机会有限,但几乎所有85岁以上的个体都需要白内障手术。

财务披露

作者对本文中讨论的任何材料均无所有权或商业利益。

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