基于纳米荧光素酶技术检测跨膜丝氨酸蛋白酶2，旨在开发抗冠状病毒药物。
NanoLuciferase technology-based detection of TMPRSS2 as attempt to develop anti-coronavirus agents.
作者信息
Chen Yanwen, Li Yunqi, Zhao Ye, Pei Lei, Zhang Ling, Zou Duowu
机构信息
Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Rd, Shanghai, 200025, China.
National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Rd, Shanghai, 200025, China.
出版信息
Biochem Biophys Rep. 2024 Jul 25;39:101783. doi: 10.1016/j.bbrep.2024.101783. eCollection 2024 Sep.
Abstract
•Utilized NanoBiT technology for high-throughput screening.•Identified compounds reducing TMPRSS2 expression, a crucial step for SARS-CoV-2 entry.•Explored a broad range of compound libraries.
摘要
•利用纳米生物发光互补技术进行高通量筛选。
•鉴定出可降低TMPRSS2表达的化合物，这是新冠病毒进入细胞的关键步骤。
•探索了广泛的化合物文库。
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