Harrington Margaret S, Di Leo Stefania D F, Hlady Courtney A, Burkhart Timothy A
Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON, Canada.
Department of Physical Therapy, University of Toronto, Toronto, ON, Canada.
Heliyon. 2024 Jul 22;10(15):e35007. doi: 10.1016/j.heliyon.2024.e35007. eCollection 2024 Aug 15.
Musculoskeletal modeling is a powerful tool to quantify biomechanical factors typically not feasible to measure , such as hip contact forces and deep muscle activations. While technological advancements in musculoskeletal modeling have increased accessibility, selecting the appropriate modeling approach for a specific research question, particularly when investigating pathological populations, has become more challenging. The purposes of this review were to summarize current modeling and simulation methods in structural hip disorder research, as well as evaluate model validation and study reproducibility. MEDLINE and Web of Science were searched to identify literature relating to the use of musculoskeletal models to investigate structural hip disorders (i.e., involving a bony abnormality of the pelvis, femur, or both). Forty-seven articles were included for analysis, which either compared multiple modeling methods or applied a single modeling workflow to answer a research question. Findings from studies comparing methods were summarized, such as the effect of generic versus patient-specific modeling techniques on model-estimated hip contact forces or muscle forces. The review also discussed limitations in validation practices, as only 11 of the included studies conducted a validation and used qualitative approaches only. Given the lack of information related to model validation, additional details regarding the development and validation of generic models were retrieved from references and modeling software documentation. To address the wide variability and under-reporting of data collection, data processing, and modeling methods highlighted in this review, we developed a template that researchers can complete and include as a table within the methodology section of their manuscripts. The use of this table will help increase transparency and reporting of essential details related to reproducibility and methods without being limited by word count restrictions. Overall, this review provides a comprehensive synthesis of modeling approaches that can help researchers make modeling decisions and evaluate existing literature.
肌肉骨骼建模是一种强大的工具，可用于量化通常难以测量的生物力学因素，如髋关节接触力和深层肌肉激活。虽然肌肉骨骼建模的技术进步提高了其可及性，但为特定研究问题选择合适的建模方法，尤其是在研究病理人群时，变得更具挑战性。本综述的目的是总结结构性髋关节疾病研究中的当前建模和模拟方法，以及评估模型验证和研究的可重复性。检索了MEDLINE和科学网，以识别与使用肌肉骨骼模型研究结构性髋关节疾病（即涉及骨盆、股骨或两者的骨异常）相关的文献。纳入47篇文章进行分析，这些文章要么比较了多种建模方法，要么应用单一建模流程来回答研究问题。总结了比较方法的研究结果，如通用建模技术与患者特异性建模技术对模型估计的髋关节接触力或肌肉力的影响。该综述还讨论了验证实践中的局限性，因为纳入的研究中只有11项进行了验证，且仅使用了定性方法。鉴于缺乏与模型验证相关的信息，从参考文献和建模软件文档中检索了有关通用模型开发和验证的更多详细信息。为了解决本综述中强调的数据收集、数据处理和建模方法的广泛变异性和报告不足问题，我们开发了一个模板，研究人员可以填写并作为表格纳入其手稿的方法部分。使用此表格将有助于提高与可重复性和方法相关的基本细节的透明度和报告，而不受字数限制。总体而言，本综述对建模方法进行了全面综合，可帮助研究人员做出建模决策并评估现有文献。
