Department of Medicinal Chemistry and Pharmaceutical Analysis, Anhui College of Traditional Chinese Medicine, Wuhu, People's Republic of China.
Wuhu Modern Technology Research and Development Center of Chinese Medicine and Functional Food, Wuhu, People's Republic of China.
Int J Nanomedicine. 2024 Aug 12;19:8189-8210. doi: 10.2147/IJN.S476948. eCollection 2024.
Ferroptosis, a unique form of regulated cell death driven by iron-dependent lethal lipid peroxidation, is implicated in various stress-related diseases like neurodegeneration, vasculopathy, and metabolic disturbance. Stress-related diseases encompass widespread medical disorders that are influenced or exacerbated by stress. These stressors can manifest in various organ or tissue systems and have significant implications for human overall health. Understanding ferroptosis in these diseases offers insights for therapeutic strategies targeting relevant pathways. This review explores ferroptosis mechanisms, its role in pathophysiology, its connection to stress-related diseases, and the potential of ferroptosis-targeted nanomedicines in treating conditions. This monograph also delves into the engineering of ferroptosis-targeted nanomedicines for tackling stress-related diseases, including cancer, cardia-cerebrovascular, neurodegenerative, metabolic and inflammatory diseases. Anyhow, nanotherapy targeting ferroptosis holds promise by both promoting and suppressing ferroptosis for managing stress-related diseases.
铁死亡是一种由铁依赖性致命脂质过氧化驱动的独特的调节性细胞死亡形式，与神经退行性疾病、血管疾病和代谢紊乱等多种应激相关疾病有关。应激相关疾病包括广泛的医学疾病，这些疾病受应激影响或恶化。这些应激源可以在不同的器官或组织系统中表现出来，并对人类整体健康有重大影响。了解这些疾病中的铁死亡机制为针对相关途径的治疗策略提供了思路。这篇综述探讨了铁死亡的机制、在病理生理学中的作用、与应激相关疾病的联系，以及铁死亡靶向纳米药物在治疗这些疾病中的潜力。本专论还深入探讨了针对应激相关疾病（包括癌症、心脏-脑血管、神经退行性、代谢和炎症性疾病）的铁死亡靶向纳米药物的工程设计。无论如何，针对铁死亡的纳米疗法通过促进和抑制铁死亡来管理应激相关疾病具有广阔的应用前景。
