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解读Toll样受体3基因多态性在口腔鳞状细胞癌发病机制中的作用：一项病例对照研究。

Deciphering the role of TLR3 polymorphisms in oral squamous cell carcinoma pathogenesis: A case-control study.

作者信息

Sharma Apoorva, Jaiswal Rohit, Singh Sarveshwarii, Asthana Prateek, Tandon Aanchal, Shakarwal Parul

机构信息

Department of Oral and Maxillofacial Pathology, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh, India.

Department of Conservative Dentistry and Endodontics, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh, India.

出版信息

J Oral Maxillofac Pathol. 2024 Apr-Jun;28(2):232-239. doi: 10.4103/jomfp.jomfp_47_24. Epub 2024 Jul 11.

DOI:10.4103/jomfp.jomfp_47_24
PMID:39157834
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11329090/
Abstract

BACKGROUND

Oral squamous cell carcinoma (OSCC) poses a significant global health burden, particularly prevalent in regions like India. Despite advancements in diagnostics, early detection of OSCC remains challenging, necessitating novel diagnostic modalities. Toll-like receptors (TLRs) and their polymorphisms have emerged as potential contributors to OSCC pathogenesis.

METHODS

This retrospective case-control study examined 120 individuals, including 60 OSCC cases and 60 healthy controls. Genotyping of TLR3 single-nucleotide polymorphisms (SNPs) rs3775290 and rs3775291 was conducted using TaqMan allelic discrimination real-time polymerase chain reaction. Functional consequence analysis and TLR3 expression profiling were performed to elucidate their role in OSCC pathogenesis.

RESULTS

Significant associations were observed between TLR3 SNPs and OSCC susceptibility, particularly at loci rs3775290 and rs3775291. Functional consequence analysis revealed pathogenic mutations in TLR3 genes, potentially affecting protein structure and function. TLR3 overexpression was detected in OSCC lesions, implicating its involvement in disease progression.

CONCLUSION

TLR3 polymorphisms play a pivotal role in OSCC pathogenesis, offering potential biomarkers for diagnosis and prognosis. Targeting TLR3-mediated pathways may hold promise in personalised OSCC management. Further research is warranted to elucidate the precise mechanisms underlying TLR3-mediated carcinogenesis in OSCC, facilitating the development of tailored therapeutic strategies.

摘要

背景

口腔鳞状细胞癌（OSCC）给全球健康带来了重大负担，在印度等地区尤为普遍。尽管诊断技术有所进步，但OSCC的早期检测仍然具有挑战性，因此需要新的诊断方法。Toll样受体（TLR）及其多态性已成为OSCC发病机制的潜在影响因素。

方法

这项回顾性病例对照研究对120名个体进行了检查，包括60例OSCC病例和60名健康对照。使用TaqMan等位基因鉴别实时聚合酶链反应对TLR3单核苷酸多态性（SNP）rs3775290和rs3775291进行基因分型。进行功能后果分析和TLR3表达谱分析以阐明它们在OSCC发病机制中的作用。

结果

观察到TLR3 SNP与OSCC易感性之间存在显著关联，特别是在rs3775290和rs3775291位点。功能后果分析揭示了TLR3基因中的致病突变，可能影响蛋白质结构和功能。在OSCC病变中检测到TLR3过表达，表明其参与疾病进展。

结论

TLR3多态性在OSCC发病机制中起关键作用，为诊断和预后提供了潜在的生物标志物。靶向TLR3介导的途径可能在个性化OSCC管理中具有前景。有必要进一步研究以阐明OSCC中TLR3介导的致癌作用的精确机制，促进定制治疗策略的开发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c395/11329090/23d0e96fd118/JOMFP-28-232-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c395/11329090/84c2aacc9807/JOMFP-28-232-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c395/11329090/17506f59941c/JOMFP-28-232-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c395/11329090/b8e91815606b/JOMFP-28-232-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c395/11329090/2f775ba5f8b3/JOMFP-28-232-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c395/11329090/99f30fc16603/JOMFP-28-232-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c395/11329090/ec525f3bb5c1/JOMFP-28-232-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c395/11329090/6f38ad94bf0c/JOMFP-28-232-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c395/11329090/23d0e96fd118/JOMFP-28-232-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c395/11329090/84c2aacc9807/JOMFP-28-232-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c395/11329090/17506f59941c/JOMFP-28-232-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c395/11329090/b8e91815606b/JOMFP-28-232-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c395/11329090/2f775ba5f8b3/JOMFP-28-232-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c395/11329090/99f30fc16603/JOMFP-28-232-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c395/11329090/ec525f3bb5c1/JOMFP-28-232-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c395/11329090/6f38ad94bf0c/JOMFP-28-232-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c395/11329090/23d0e96fd118/JOMFP-28-232-g008.jpg

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