基于分子电荷的高亲和力人血清白蛋白模板分子印迹聚合物纳米粒子的电监测及其可视化。
Electrical monitoring of human-serum-albumin-templated molecularly imprinted polymer nanoparticles with high affinity based on molecular charges and their visualization.
机构信息
Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
Department of Chemical and Biomolecular Engineering, University of California, Berkeley, USA.
出版信息
Chem Commun (Camb). 2024 Sep 5;60(72):9769-9772. doi: 10.1039/d4cc03541k.
Human-serum-albumin (HSA)-templated molecularly imprinted polymer nanoparticles (nano-MIPs) were integrated with a solution-gated field-effect transistor-based biosensor. The real-time electrical analysis of nano-MIP-HSA binding showed a high affinity and specificity of nano-MIPs for HSA. Moreover, the binding behaviour was continuously visualised using a solution-gated complementary metal-oxide semiconductor array image biosensor.
人血清白蛋白（HSA）模板的分子印迹聚合物纳米粒子（nano-MIPs）与基于溶液门场效应晶体管的生物传感器集成。nano-MIP-HSA 结合的实时电分析显示 nano-MIPs 对 HSA 具有高亲和力和特异性。此外，使用溶液门互补金属氧化物半导体阵列图像生物传感器连续可视化结合行为。
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