College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, P. R. China.
Biomater Sci. 2024 Sep 25;12(19):4855-4874. doi: 10.1039/d4bm00865k.
In recent years, supramolecular hydrogels have made groundbreaking research progress in biomedical fields such as drug delivery, biosensing, imaging analysis, and tissue engineering. Peptides, with their unique characteristics of facile preparation, low immunogenicity and easy biodegradability, are commonly used as building blocks of supramolecular hydrogels. Peptide-based supramolecular hydrogels loaded with drugs, prepared physical means or covalent crosslinking, exhibit unique three-dimensional network structures and strong water retention capacities. These properties enhance drug bioavailability and reduce side effects, enabling drug accumulation and responsive release at disease sites, significantly improving the therapeutic efficacy. Here, we review recent advancements in peptide-based supramolecular hydrogels and their biotherapeutic applications, including chemotherapy, photothermal therapy, photodynamic therapy, immunotherapy, gene therapy, antibacterial and anti-inflammatory treatments, and other biological applications. This review aims to provide new inspiration for the development of biomaterials in the therapeutic field and provide more personalized options for disease treatment. Additionally, challenges and limitations in this field are briefly discussed.
近年来，超分子水凝胶在药物输送、生物传感、成像分析和组织工程等生物医学领域取得了突破性的研究进展。肽具有制备简便、免疫原性低和可生物降解等独特特性，常被用作超分子水凝胶的构建模块。基于肽的超分子水凝胶通过物理手段或共价交联负载药物，具有独特的三维网络结构和强持水能力。这些特性提高了药物的生物利用度，降低了副作用，使药物在疾病部位积累并响应释放，显著提高了治疗效果。本文综述了近年来基于肽的超分子水凝胶及其在生物治疗中的应用，包括化学治疗、光热治疗、光动力治疗、免疫治疗、基因治疗、抗菌和抗炎治疗以及其他生物学应用。本文旨在为治疗领域中生物材料的发展提供新的思路，并为疾病治疗提供更个性化的选择。此外，本文还简要讨论了该领域面临的挑战和限制。
