Bamberg Fabian, Schlett Christopher L, Caspers Svenja, Ringhof Steffen, Günther Matthias, Hirsch Jochen G, Rüdebusch Julia, Miklánková Pavlína, Bittner Nora, Jockwitz Christiane, Forsting Michael, Hosten Norbert, Kaaks Rudolph, Kauczor Hans-Ulrich, Kroenke Thomas, Niendorf Thoralf, Peters Annette, Pischon Tobias, Stang Andreas, Berger Klaus, Völzke Henry
Department of Radiology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Institute for Epidemiology and Social Medicine, University of Münster, Germany; Institute for Community Medicine, University Medical Center Greifswald, Germany; Institute for Anatomy I, Faculty of Medicine, University Hospital Düsseldorf, Heinrich-Heine-University of Düsseldorf; Institute for The Neurosciences and Medicine (INM-1), Research Center Jülich; Department of Radiology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Fraunhofer Institute for Digital Medicine MEVIS, Bremen; Institute for Community Medicine, University Medical Center Greifswald; Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg; Institute for Diagnostic Radiology and Neuroradiology, University Medical Center Greifswald; Institute for Diagnostic and Interventional Radiology and Neuroradiology,University Medical Center Essen, University of Duisburg-Essen; Institute for Epidemiology, Helmholtz Center Munich - German Research Center for Health and the Environment, Neuherberg; Institute for Medical Data Processing, Biometrics, and Epidemiology, Faculty of Medicine, Ludwig-Maximilians-University of Munich; Department of Cancer Epidemiology, German Cancer Research Center (DKFZ) Heidelberg; Department of Diagnostic and Interventional Radiology, University Hospital Augsburg; Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine in the Helmholtz Gesellschaft (MDC), Berlin; German Center for Diabetes Research (DZD), Neuherberg; German Center for Cardiovascular Research (DZHK), Munich Heart Alliance, Munich; Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine in the Helmholtz Gesellschaft (MDC), Berlin; Biobank Technology Platform, Max Delbrück Center for Molecular Medicine in the Helmholtz Gesellschaft (MDC), Berlin; Charité University Medical Center Berlin; Institute for Medical Informatics, Biometrics, and Epidemiology, University Medical Center Essen, University of Duisburg-Essen.
Dtsch Arztebl Int. 2024 Sep 6;121(18):587-593. doi: 10.3238/arztebl.m2024.0151.
Magnetic resonance imaging (MRI) yields important information on the development and current status of many different diseases. Whole-body MRI was accordingly made a part of the multicenter, population-based NAKO Health Study. The present analysis concerns the feasibility of the baseline MRI examination and various aspects of quality assurance over the period 2014-2019.
32 252 participants in the NAKO Health Study, aged 20 to 74, who had no contraindication to MRI were invited to undergo scanning in one of five MRI study centers across Germany. The whole-body MRI scan took about one hour and consisted of sequences for the visualization of structural and functional features of the brain, musculoskeletal system, cardiovascular system, and thoracoabdominal system. A comprehensive quality-assurance assessment was carried out, with evaluation of adverse events, the completeness of the MRI protocols, the participants' subjective perceptions, and image quality.
31 578 participants (97.9%) were successfully included in the MRI study. They reported a high level of comfort and suffered no severe adverse events (mild adverse events occurred in only four participants). Depending on the imaging sequence, the image quality was rated as excellent in 80.2% to 96.8% of cases. Quality assessment with respect to structural features of the brain revealed high consistency across study centers, as well as with regard to age- and sex-based differences in brain volume (men, 1203.81 ± 102.06 cm³; women, 1068.10 ± 86.69 cm³).
Whole-body MRI was successfully implemented in the NAKO baseline examination and was associated with high patient comfort and very good image quality. The imaging biomarkers of the brain confirmed previously observed differences based on age and sex, underscoring the feasibility of data pooling.
磁共振成像（MRI）可提供有关多种不同疾病的发展及当前状况的重要信息。因此，全身MRI成为了基于人群的多中心NAKO健康研究的一部分。本分析涉及2014年至2019年期间基线MRI检查的可行性及质量保证的各个方面。
NAKO健康研究中32252名年龄在20至74岁之间且无MRI检查禁忌证的参与者受邀在德国五个MRI研究中心之一接受扫描。全身MRI扫描耗时约一小时，包括用于显示脑、肌肉骨骼系统、心血管系统和胸腹系统结构及功能特征的序列。进行了全面的质量保证评估，包括对不良事件、MRI方案的完整性、参与者的主观感受和图像质量的评估。
31578名参与者（97.9%）成功纳入MRI研究。他们表示舒适度很高，未发生严重不良事件（仅四名参与者发生轻度不良事件）。根据成像序列，80.2%至96.8%的病例图像质量被评为优秀。关于脑结构特征的质量评估显示，各研究中心之间以及基于年龄和性别的脑容量差异方面（男性，1203.81±102.06立方厘米；女性，1068.10±86.69立方厘米）具有高度一致性。
全身MRI在NAKO基线检查中成功实施，且患者舒适度高，图像质量非常好。脑成像生物标志物证实了先前观察到的基于年龄和性别的差异，强调了数据汇总的可行性。
