State Key Laboratory of Powder Metallurgy, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, China.
College of Material, Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Key Laboratory of Organosilicon Material Technology of Zhejiang Province, Hangzhou Normal University, Hangzhou, 311121, China.
Chemistry. 2024 Nov 26;30(66):e202402624. doi: 10.1002/chem.202402624. Epub 2024 Oct 21.
Supramolecular chemistry achieves higher-order molecular self-assembly through non-covalent interactions. Utilizing supramolecular methods to explore the polymorphism of proteins, the building blocks of life, from a "bottom-up" perspective is essential for constructing diverse and functional biomaterials. In recent years, significant progress has been achieved in the design strategies and functional applications of supramolecular protein self-assembly, becoming a focal point for researchers. This paper reviews classical supramolecular strategies driving protein self-assembly, including electrostatic interactions, metal coordination, hydrogen bonding, hydrophobic interactions, host-guest interactions, and other mechanisms. We discuss how these supramolecular interactions regulate protein assembly processes and highlight protein supramolecular assemblies' unique structural and functional advantages in constructing artificial photosynthetic systems, protein hydrogels, bio-delivery systems, and other functional materials. The enormous potential and significance of supramolecular protein materials are elucidated. Finally, the challenges in preparing and applying protein supramolecular assemblies are summarized, and future development directions are projected.
超分子化学通过非共价相互作用实现更高阶的分子自组装。利用超分子方法从“自下而上”的角度探索生命基石——蛋白质的多态性，对于构建多样化和功能化的生物材料至关重要。近年来，超分子蛋白质自组装的设计策略和功能应用方面取得了重大进展，成为研究人员关注的焦点。本文综述了驱动蛋白质自组装的经典超分子策略，包括静电相互作用、金属配位、氢键、疏水相互作用、主体-客体相互作用等机制。我们讨论了这些超分子相互作用如何调节蛋白质组装过程，并强调了蛋白质超分子组装在构建人工光合作用系统、蛋白质水凝胶、生物传递系统和其他功能材料方面的独特结构和功能优势。阐明了超分子蛋白质材料的巨大潜力和意义。最后，总结了制备和应用蛋白质超分子组装所面临的挑战，并展望了未来的发展方向。
