He Bin, Phansavath Phannarath, Ratovelomanana-Vidal Virginie
PSL University , Chimie ParisTech, CNRS, Institute of Chemistry for Life and Health Sciences , CSB2D Team , 75005 Paris , France.
Org Lett. 2019 May 3;21(9):3276-3280. doi: 10.1021/acs.orglett.9b01002. Epub 2019 Apr 15.
Enantioenriched cis-3-(hydroxymethyl)chroman-4-ol derivatives were conveniently prepared by rhodium-catalyzed asymmetric transfer hydrogenation of 3-formylchromones through a dynamic kinetic resolution process. The reaction proceeded under mild conditions using a low catalyst loading and HCOH/EtN (5:2) as the hydrogen source, delivering the reduced compounds in good yields, high diastereomeric ratio (up to 98:2 dr), and excellent enantioselectivities (up to >99% ee).
通过铑催化的3-甲酰基色酮的不对称转移氢化，经由动态动力学拆分过程，可方便地制备对映体富集的顺式-3-(羟甲基)色满-4-醇衍生物。该反应在温和条件下进行，使用低催化剂负载量，以HCOH/EtN(5:2)作为氢源，以良好的产率、高非对映体比率（高达98:2 dr）和优异的对映选择性（高达>99% ee）得到还原产物。
