Medical University of South Carolina, Charleston. Dr. Barker is from the Department of Internal Medicine. Drs. Elston and Lee are from the Department of Dermatology and Dermatologic Surgery.
Cutis. 2024 Jul;114(1):E31-E34. doi: 10.12788/cutis.1063.
A generalized fixed drug eruption (FDE) is an uncommon but potentially dangerous reaction to medication. In this case series, we present 1 patient with a generalized FDE and 2 patients with generalized bullous FDE that resolved with cyclosporine, though 1 patient required close monitoring in the intensive care unit. Immediate acceleration of care upon development and recognition of generalized bullous FDE is essential, as the mortality rate is similar to Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN).
全身性固定性药物疹（FDE）是一种不常见但可能危及生命的药物不良反应。在本病例系列中，我们报告了 1 例全身性 FDE 和 2 例全身性大疱性 FDE 患者，他们均接受环孢素治疗后得到缓解，但 1 例患者需要在重症监护病房密切监测。一旦出现全身性大疱性 FDE，应立即加速治疗，因为其死亡率与史蒂文斯-约翰逊综合征（SJS）/中毒性表皮坏死松解症（TEN）相似。
