Goffin Y A, McCrickard E L, Ameryckx J P, Malmendier C L, Hiden M, Cornwell G G
Appl Pathol. 1985;3(1-2):88-95.
Amyloid-containing tissues were sampled from 19 capsules and 10 cartilages from hip, knee and sternoclavicular joints of 16 elderly patients. Heart ventricles from 3 of these patients were also studied. Histochemistry and immunofluorescence were performed and amyloid fibrils extracted from one hip capsule. The results indicate that 9 of 13 hip capsules contained prealbumin-like amyloid fibril protein ASc1, a finding characteristic of senile systemic amyloidosis. The amyloid of 16 out of 17 other joint structures showed no reaction with anti-ASc1 or antisera to 3 other systemic forms of amyloid, indicating that they represent localized forms of amyloid.
从16名老年患者的19个关节囊以及髋、膝和胸锁关节的10块软骨中采集含淀粉样蛋白的组织样本。还对其中3名患者的心室进行了研究。进行了组织化学和免疫荧光检测，并从一个髋关节囊中提取了淀粉样纤维。结果表明，13个髋关节囊中，有9个含有前白蛋白样淀粉样纤维蛋白ASc1，这是老年系统性淀粉样变性的一个特征性发现。其他17个关节结构中的16个的淀粉样蛋白，与抗ASc1或针对其他3种系统性淀粉样蛋白形式的抗血清均无反应，表明它们代表局部性淀粉样蛋白形式。
