Cornwell G G, Westermark P, Murdoch W, Pitkänen P
Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire 03755.
Am J Pathol. 1982 Aug;108(2):135-9.
Aortic tissues from 22 elderly patients were analyzed by Congo red staining for amyloid deposits. All samples contained amyloid, which was resistant to the potassium permanganate reaction. Tryptophan was present in all amyloid deposits. The amyloid failed to react with antiserums to amyloid fibril protein ASc1 or human prealbumin, proteins previous demonstrated in generalized senile cardiac amyloid. It also differed from age-related isolated atrial amyloid, which has been shown to lack tryptophan. Deposits did not react with antiserums specific for amyloid fibril proteins of the A lambda IV, A lambda VI, AA, or AEt types. These results indicate that senile aortic amyloid is distinct from amyloid present in primary and secondary amyloidosis and appears to represent a third form of cardiovascular amyloid associated with the aging process.
对22例老年患者的主动脉组织进行刚果红染色，分析淀粉样沉积物。所有样本均含有淀粉样蛋白，该蛋白对高锰酸钾反应具有抗性。所有淀粉样沉积物中均存在色氨酸。该淀粉样蛋白不能与抗淀粉样原纤维蛋白ASc1或人前白蛋白的抗血清发生反应，而这两种蛋白先前已在全身性老年心脏淀粉样变中得到证实。它也不同于与年龄相关的孤立性心房淀粉样变，后者已被证明缺乏色氨酸。沉积物不能与针对AλIV、AλVI、AA或AEt型淀粉样原纤维蛋白的特异性抗血清发生反应。这些结果表明，老年主动脉淀粉样变不同于原发性和继发性淀粉样变中存在的淀粉样蛋白，似乎代表了与衰老过程相关的第三种心血管淀粉样变形式。
