Chin Jia Ying, Tong Louis, Liu Chang, Lee Isabelle Xin Yu, Wong Jipson Hon Fai, Wong Regina Kay Ting, Mehta Jodhbir S, Liu Yu-Chi
Corneal Research Group, Singapore Eye Research Institute, Singapore, Singapore.
Department of Cornea and External Eye Disease, Singapore National Eye Centre, Singapore, Singapore.
Cornea. 2024 Aug 20. doi: 10.1097/ICO.0000000000003674.
To investigate and compare the quality of life (QoL) and symptomatology between neuropathic corneal pain (NCP) and dry eye disease (DED).
We recruited 150 patients, comprising 50 patients with NCP and 100 patients with DED. Patients' symptoms and QoL were evaluated using the Ocular Pain Assessment Survey and Ocular Surface Disease Index questionnaires. Ocular surface assessments were also performed.
Patients with NCP demonstrated significantly lower Oxford and National Eye Institute scores for ocular surface and corneal staining, respectively, and a better tear break-up time than patients with DED. However, patients with NCP reported significantly worse scores on most of the Ocular Pain Assessment Survey questions and significantly more severe overall pain (P = 0.019), maximal and average ocular pain and nonocular pain (all P < 0.05). The NCP group reported significantly worse QoL in all aspects of daily living (all P < 0.001). Patients with NCP spent more time thinking about their eye pain and reported significantly higher pain intensities than patients with DED when exposed to chemical and mechanical stimuli (all P ≤ 0.008). Burning sensation and photophobia were significantly more frequent in patients with NCP (P = 0.032 and P = 0.012, respectively). Similarly, the NCP group reported significantly worse total Ocular Surface Disease Index scores, significantly more frequent vision-related function impairment and painful or sore eyes than the DED group (P = 0.029, P = 0.031, and P = 0.014, respectively).
Compared with DED, NCP is more debilitating, leading to more severe and frequent symptoms, and greater negative impact on all aspects of QoL.
研究并比较神经性角膜疼痛（NCP）和干眼疾病（DED）患者的生活质量（QoL）及症状表现。
我们招募了150名患者，其中50名患有NCP，100名患有DED。使用眼痛评估调查问卷和眼表疾病指数问卷对患者的症状和生活质量进行评估。同时也进行了眼表评估。
NCP患者的牛津眼表评分和美国国立眼科研究所角膜染色评分分别显著低于DED患者，且泪膜破裂时间比DED患者更长。然而，在大多数眼痛评估调查问卷问题上，NCP患者的得分显著更差，总体疼痛也明显更严重（P = 0.019），最大和平均眼痛以及非眼痛均更严重（所有P < 0.05）。NCP组在日常生活的各个方面生活质量均显著更差（所有P < 0.001）。与DED患者相比，NCP患者花更多时间思考眼痛问题，并且在接触化学和机械刺激时报告的疼痛强度显著更高（所有P≤0.008）。NCP患者的烧灼感和畏光症状明显更频繁（分别为P = 0.032和P = 0.012）。同样，NCP组的眼表疾病指数总分显著更差，与视力相关的功能损害以及眼痛或眼痛症状比DED组更频繁（分别为P = 0.029、P = 0.031和P = 0.014）。
与DED相比，NCP的致残性更强，会导致更严重、更频繁的症状，对生活质量的各个方面产生更大的负面影响。
