Ng Debbie Marie, Wang Xiu, Liu Chang, Yu MingYi, Lee Isabelle Xin Yu, Wong Jipson Hon Fai, Wong Regina Kay Ting, Chan Diana Xin Hui, Liu Yu-Chi, Tong Louis Hak Tien
Ocular Surface Research Group, Singapore Eye Research Institute, Singapore, Singapore.
Tianjin Key Laboratory of Retinal Function and Diseases, Tianjin Branch of National Clinical, Research Centre for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical, University Eye Hospital, Tianjin, China.
Transl Vis Sci Technol. 2025 Feb 3;14(2):20. doi: 10.1167/tvst.14.2.20.
The Ocular Pain Assessment Survey (OPAS) has been used to quantify chronic ocular pain and quality of life (QOL). We aim to investigate the psychometric properties of individual OPAS items with the Rasch analysis in an Asian population of dry eye disease and neuropathic corneal pain (NCP).
Question responses were obtained from 196 patients; 138 with dry eye disease (DED) and 58 with NCP, at the Singapore National Eye Centre. Item hierarchy, item fit statistics, item separation, reliability indices, and Yen's Q3 values were calculated.
Individual dimensions that quantify eye pain levels in the past 24 hours and QOL showed good discriminative ability according to their person separation index values. However, individual dimensions that measured eye pain in the past 2 weeks, non-eye pain, as well as aggravating and associated factors showed suboptimal person separation index values. Significant correlations were found between the individual item pairs of the aggravating factors dimension as well as between some of the items in the QOL and associated factors dimensions.
Two dimensions of the OPAS questionnaire were validated with the Rasch analysis. Based on these findings, we shorten the number of questions in some dimensions to improve the performance of the tool in similar Asian populations.
Our study provides insights to improve the existing OPAS for real-world clinical applications and clinical trials.
眼部疼痛评估调查（OPAS）已被用于量化慢性眼部疼痛和生活质量（QOL）。我们旨在通过拉施分析研究在亚洲干眼症和神经性角膜疼痛（NCP）人群中OPAS各项目的心理测量特性。
在新加坡国家眼科中心，从196例患者中获取问题回答；其中138例患有干眼症（DED），58例患有NCP。计算项目层次结构、项目拟合统计量、项目区分度、信度指标和严氏Q3值。
根据其个人区分指数值，量化过去24小时眼部疼痛程度和生活质量的各个维度显示出良好的区分能力。然而，测量过去2周眼部疼痛、非眼部疼痛以及加重因素和相关因素的各个维度显示出次优的个人区分指数值。在加重因素维度的各个项目对之间以及生活质量和相关因素维度的一些项目之间发现了显著相关性。
通过拉施分析验证了OPAS问卷的两个维度。基于这些发现，我们缩短了某些维度的问题数量，以提高该工具在类似亚洲人群中的性能。
我们的研究为改进现有的OPAS用于实际临床应用和临床试验提供了见解。
