韩国成年人中使用甘油三酯-葡萄糖指数评估电子烟吸烟与胰岛素抵抗之间的关联：韩国国民健康与营养检查调查

Association between E-Cigarette Smoking and Insulin Resistance Using the Triglyceride-Glucose Index in Korean Adults: Korea National Health and Nutrition Examination Survey.

作者信息

Lim Dahae, Choi Jung In, Kwon Ryuk Jun, Lee Sang Yeoup, Cho Young Hye, Park Eun Ju, Lee Youngin, Lee Sae Rom, Son Soo Min, Kim Yun Jin, Lee Jeong Gyu, Yi Yu Hyeon, Tak Young Jin, Lee Seung Hun, Kim Gyu Lee, Ra Young Jin

机构信息

Department of Family Medicine and Biomedical Research Institute, Pusan National University Yangsan Hospital, Yangsan, Korea.

Department of Family Medicine, Pusan National University School of Medicine, Yangsan, Korea.

出版信息

Korean J Fam Med. 2024 Aug 20. doi: 10.4082/kjfm.23.0141.

DOI:10.4082/kjfm.23.0141

PMID:39160688

Abstract

BACKGROUND

Insulin resistance contributes to the development of cardiovascular disease and type 2 diabetes mellitus. Smoking leads to an increase in triglyceride levels, which, in turn, increases insulin resistance. Although the number of e-cigarette users has increased in recent years, few studies have investigated the association between ecigarette use and insulin resistance. Therefore, this study aimed to determine the association between e-cigarette use and insulin resistance using the triglyceride-glucose (TyG) index in Korean adults.

METHODS

This study included 4,404 healthy adults aged ≥20 years who participated in the Korea National Health and Nutrition Examination Survey between 2019 and 2020. Participants were categorized as never-smokers or ecigarette users, and the TyG index was categorized into low- and high-TyG index groups according to the median value (9.22). A logistic regression analysis was performed to determine the association between e-cigarette smoking and insulin resistance.

RESULTS

E-cigarette users had a higher TyG index than never smokers (e-cigarette: mean=3.95; never: mean=9.18; P<0.001). The e-cigarette users had a higher risk of being in the high TyG index group than never-smokers (odds ratio [OR], 1.38; 95% confidence interval [CI], 1.03-1.84). In the subgroup analysis stratified by sex, age, and body mass index, a higher OR for a high TyG index was observed in men (OR, 1.46; 95% CI, 1.03-2.08) and individuals aged 60 years or older (OR, 3.74; 95% CI, 1.14-12.30).

CONCLUSION

Our findings suggest that e-cigarette use is significantly associated with insulin resistance.

摘要

背景

胰岛素抵抗会促使心血管疾病和2型糖尿病的发展。吸烟会导致甘油三酯水平升高，进而增加胰岛素抵抗。尽管近年来电子烟使用者的数量有所增加，但很少有研究调查电子烟使用与胰岛素抵抗之间的关联。因此，本研究旨在利用甘油三酯-葡萄糖（TyG）指数确定韩国成年人中电子烟使用与胰岛素抵抗之间的关联。

方法

本研究纳入了2019年至2020年期间参加韩国国民健康与营养检查调查的4404名年龄≥20岁的健康成年人。参与者被分为从不吸烟者或电子烟使用者，TyG指数根据中位数（9.22）分为低TyG指数组和高TyG指数组。进行逻辑回归分析以确定电子烟吸烟与胰岛素抵抗之间的关联。

结果

电子烟使用者的TyG指数高于从不吸烟者（电子烟：平均值 = 3.95；从不吸烟者：平均值 = 9.18；P < 0.001）。与从不吸烟者相比，电子烟使用者处于高TyG指数组的风险更高（优势比[OR]，1.38；95%置信区间[CI]，1.03 - 1.84）。在按性别、年龄和体重指数分层的亚组分析中，男性（OR，1.46；95% CI，1.03 - 2.08）和60岁及以上的个体（OR，3.74；95% CI，1.14 - 12.30）的高TyG指数的OR更高。